The study of drug metabolism is a cornerstone of pharmaceutical science, providing critical insights into how therapeutic agents are processed by the body. Nifedipine, a widely used calcium channel blocker, undergoes several metabolic transformations, yielding various metabolites. Among the most significant of these is Dehydro Nifedipine (CAS 67035-22-7), often also referred to as Oxidized Nifedipine. Understanding this compound's role is vital for researchers in pharmacology, drug development, and analytical chemistry.

Dehydro Nifedipine is identified as a principal metabolite of Nifedipine found in human plasma. Its formation is largely attributed to the enzymatic activity of cytochrome P450 (CYP) enzymes, specifically CYP3A4 and CYP3A5. These enzymes are crucial for the biotransformation of xenobiotics, including many pharmaceuticals. The presence and concentration of Dehydro Nifedipine in biological samples offer valuable information regarding Nifedipine's metabolic pathways and the efficiency of its clearance from the body.

For researchers, Dehydro Nifedipine serves as an essential tool. It is frequently used as a reference standard in analytical assays to confirm and quantify Nifedipine metabolism in clinical and preclinical studies. This capability is fundamental for pharmacokinetic profiling, which examines the absorption, distribution, metabolism, and excretion (ADME) of a drug. Accurate measurements of Dehydro Nifedipine help researchers understand how individual variability in drug metabolism might affect treatment outcomes or the risk of drug interactions.

Furthermore, Dehydro Nifedipine's significance extends to its potential biological activity. While Nifedipine is the primary active compound, understanding the activities of its metabolites, even if less potent, is part of a comprehensive drug safety evaluation. Researchers may investigate Dehydro Nifedipine for any residual effects or specific interactions it might have within biological systems.

Procuring high-quality Dehydro Nifedipine is a key concern for research laboratories. As a specialized chemical, it is typically sourced from manufacturers who guarantee high purity, often exceeding 98%. Buyers typically seek out reliable suppliers that can provide consistent product quality and availability. Sourcing from established manufacturers in regions like China offers access to these specialized compounds at competitive prices, often with robust quality assurance protocols in place. When purchasing, it is always advisable to request a Certificate of Analysis (CoA) to verify the compound's identity, purity, and specifications.

In summary, Dehydro Nifedipine (CAS 67035-22-7) is a critical component in the study of Nifedipine pharmacology and metabolism. Its role as a key metabolite makes it indispensable for pharmacokinetic research, drug development, and analytical method validation. Ensuring access to high-purity Dehydro Nifedipine from trusted manufacturers is a fundamental step for any research endeavor involving Nifedipine or related cardiovascular therapies.