For chemists engaged in pharmaceutical research and development (R&D), a deep understanding of key intermediates is fundamental to driving innovation. Dibenz[b,e]oxepin-11(6H)-one (CAS 4504-87-4) stands out as a compound of particular importance, primarily due to its established role in the synthesis of the widely used antidepressant, doxepin, and its potential in exploring novel therapeutic agents.

The primary utility of Dibenz[b,e]oxepin-11(6H)-one in pharmaceutical R&D lies in its structural framework. As a precursor to doxepin, a tricyclic compound, it provides a ready-made dibenz[b,e]oxepin core structure. This allows R&D chemists to focus on the subsequent synthetic steps, such as side-chain additions and functional group modifications, to generate doxepin and its analogues. The availability of this intermediate from reliable manufacturers, often with high purity (e.g., >98% or 99%), ensures that early-stage research and development activities are built upon a foundation of reliable chemical input.

Beyond its direct application in doxepin synthesis, Dibenz[b,e]oxepin-11(6H)-one can serve as a versatile building block for creating a diverse library of novel compounds. Its unique fused ring system and reactive carbonyl group offer opportunities for various chemical transformations, including reduction, oxidation, and nucleophilic additions. These reactions can lead to new chemical entities with potential pharmacological activities in areas beyond depression, such as antihistamines or anti-inflammatory agents, which have historically been explored with related structures.

Furthermore, Dibenz[b,e]oxepin-11(6H)-one is noted as a photodecomposition product of doxepin. This characteristic is crucial for R&D efforts focused on drug stability and formulation. By understanding how doxepin degrades, researchers can develop more stable formulations or study the metabolic pathways of the drug. Having access to pure samples of such degradation products is essential for analytical method development and validation in pharmaceutical quality control.

For R&D chemists looking to source Dibenz[b,e]oxepin-11(6H)-one, it is important to partner with suppliers who not only provide the material but also offer technical support. Understanding the compound's physical and chemical properties, potential reaction hazards, and optimal handling procedures can significantly streamline research efforts. The ability to buy this intermediate at reasonable prices, especially for smaller R&D quantities, from manufacturers in China, further supports the ongoing discovery and development pipeline.

In essence, Dibenz[b,e]oxepin-11(6H)-one is more than just a chemical; it's a gateway to developing important pharmaceuticals and exploring new therapeutic avenues. Its consistent availability and high quality from trusted suppliers are invaluable assets for any pharmaceutical R&D team.