In the competitive landscape of chemical and pharmaceutical manufacturing, a thorough understanding of key intermediates is crucial for efficient operations and product innovation. Diethyl Acetamidomalonate (DEAM), identified by CAS 1068-90-2, is a prime example of such an intermediate, offering significant versatility in organic synthesis applications. This article aims to provide B2B clients with essential information regarding its properties, synthesis, and best practices for sourcing.

Diethyl Acetamidomalonate is characterized by its chemical formula C9H15NO5 and a molecular weight of 217.22 g/mol. Typically appearing as a white to yellow or pink crystalline powder, it exhibits good solubility in common organic solvents like methanol and chloroform, while having low water solubility. Its melting point generally falls between 95-98°C, and its boiling point is around 185°C at 20 mmHg. These physical and chemical properties make it amenable to various reaction conditions commonly employed in synthesis.

The synthesis of Diethyl Acetamidomalonate often involves multistep procedures starting from diethyl malonate or related precursors. One common method includes the preparation of diethyl isonitrosomalonate, followed by reduction and acetylation. Chemical manufacturers continually refine these processes to optimize yield, purity, and cost-effectiveness. For businesses looking to buy this intermediate, understanding the synthesis route can help in evaluating supplier quality and process consistency.

The utility of DEAM spans across several critical industries. Its most prominent application is as an intermediate in the synthesis of α-amino acids, essential components for pharmaceuticals, peptides, and biochemical research. It also serves as a precursor for α-hydroxycarboxylic acids and plays a vital role in the production of pharmaceuticals like Fingolimod and various vitamins (e.g., B1, B6). For procurement managers, identifying a reliable supplier, especially from manufacturers in China known for their chemical production capabilities, is key to ensuring a stable supply of high-purity material (≥99.0%).

When sourcing Diethyl Acetamidomalonate, B2B clients should focus on factors such as consistent quality, competitive pricing, reliable delivery, and comprehensive technical documentation. Requesting quotes from multiple manufacturers and comparing their product specifications, quality control measures, and customer service is a recommended approach. Establishing a strong relationship with a trusted manufacturer can streamline the procurement process and support long-term project success.