In the chemical and pharmaceutical industries, the precise specifications of raw materials are the bedrock of reliable synthesis and product quality. For a complex chiral molecule like (1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS: 18680-27-8), adhering to and verifying these specifications is non-negotiable. Whether you are a procurement manager seeking a stable supply or a research scientist developing new applications, understanding these parameters is crucial.

Key Specifications to Consider

The utility of (1S,2S,3R,5S)-(+)-2,3-Pinanediol stems from its well-defined chemical and physical properties. The most critical specifications typically include:

  • Purity: This is often the most important parameter. For pharmaceutical applications, particularly as an intermediate for drugs like Bortezomib, a purity of ≥99.0% (by GC) is standard. Higher purity ensures fewer side reactions and a cleaner synthesis pathway.
  • Appearance: The compound is typically described as a white crystalline powder or crystals. Any deviation from this can indicate potential contamination or degradation.
  • Optical Activity: As a chiral molecule, its optical rotation is a key indicator of its enantiomeric purity. The specification usually states a range for the specific rotation, often denoted as [α]D, which confirms it is the correct stereoisomer. For example, values around +8.5° (c=6.5, toluene) are commonly cited.
  • Melting Point: A narrow melting point range, such as 53-57°C, is indicative of a pure compound and consistent manufacturing.
  • Solubility: Information on solubility in common organic solvents (like chloroform, toluene) is important for understanding its handling and use in reaction mixtures.
  • Water Content: For moisture-sensitive reactions, specifying a maximum water content might also be relevant.

Why These Specifications Matter

These specifications are not arbitrary. For pharmaceutical synthesis, deviations in purity or optical activity can lead to reduced efficacy of the final drug product or even the formation of toxic isomers. In the fragrance industry, subtle differences in trace impurities can significantly alter the aroma profile. Therefore, always ensure that the Certificate of Analysis (COA) provided by the manufacturer accurately reflects these critical parameters.

Choosing a Reliable Supplier

When you buy (1S,2S,3R,5S)-(+)-2,3-Pinanediol, it is imperative to partner with a manufacturer and supplier who can consistently meet these specifications. We pride ourselves on being such a supplier. We understand that for advanced chemical synthesis, reliability is key. Our commitment is to provide you with high-purity, well-characterized (1S,2S,3R,5S)-(+)-2,3-Pinanediol, backed by comprehensive documentation. We aim to be your trusted source for critical chemical intermediates, ensuring your research and production processes are supported by the highest quality materials available.

By paying close attention to the specifications of (1S,2S,3R,5S)-(+)-2,3-Pinanediol, you ensure the integrity and success of your chemical projects. Partner with us for a dependable supply of this essential chiral intermediate.