Sulfonamide functional groups are ubiquitous in medicinal chemistry, appearing in a vast array of drugs that target diverse biological pathways. Their inherent chemical properties make them excellent candidates for forming hydrogen bonds and interacting with biological targets. Within this broad class, specific sulfonamide intermediates play a crucial role in the synthesis of complex APIs. One such example is N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (CAS: 918504-27-5), a key component in the manufacture of Vemurafenib.

As a leading manufacturer specializing in pharmaceutical intermediates, our company places paramount importance on the quality and consistency of our sulfonamide products. Our synthesis of CAS 918504-27-5 is designed to yield a product with a guaranteed assay of ≥98.0%. This high level of purity is critical because sulfonamides can sometimes undergo side reactions, and any impurities could carry through the synthesis, potentially compromising the efficacy or safety of the final drug product. Therefore, sourcing from a trusted manufacturer is essential.

The chemical structure of this intermediate, C17H14BrF2N3O3S, with a molecular weight of 458.27700, highlights its complexity. It features a sulfonamide moiety directly attached to a fluorinated phenyl ring, which is further linked to a brominated pyrrolo[2,3-b]pyridine system. This sophisticated architecture necessitates precise chemical engineering and quality control during its production. We provide this material as a white to yellow crystalline powder, a stable form suitable for various synthetic applications.

For procurement professionals in the pharmaceutical sector, ensuring a dependable supply of high-quality intermediates is a strategic priority. We operate as a dedicated manufacturer in China, offering bulk quantities of N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, typically packaged in 25 kg drums. Our aim is to support the entire lifecycle of drug development, from early-stage R&D to commercial-scale manufacturing. When you need to buy this specific sulfonamide intermediate, our company provides the reliability and quality you require.

The efficacy of targeted therapies like Vemurafenib is directly linked to the quality of their constituent parts. By meticulously controlling the synthesis and purity of our intermediates, we contribute to the advancement of cancer treatments. We invite pharmaceutical companies looking for a steadfast supplier of essential sulfonamide intermediates to inquire about our offerings. Partnering with us means gaining access to high-purity chemicals manufactured under rigorous quality management systems, ensuring the success of your synthesis projects.