In the complex landscape of Active Pharmaceutical Ingredient (API) manufacturing, the selection of reliable and high-quality chemical intermediates is a cornerstone of success. Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate, known by its CAS number 221675-35-0, stands out as a crucial building block in the synthesis of various APIs. This article explores the integral role this compound plays in API production and highlights what pharmaceutical manufacturers should consider when sourcing it.

The chemical structure of Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate, with its fused heterocyclic rings, makes it a versatile intermediate for creating diverse and complex molecular architectures commonly found in pharmaceuticals. Its molecular formula is C10H10N2O2, and it is typically supplied with a high purity of 99% minimum. This high degree of purity is non-negotiable in API manufacturing, as it directly influences the final API's quality, efficacy, and safety profile. Manufacturers who buy this intermediate must ensure their suppliers maintain stringent quality control measures.

As a key pharmaceutical intermediate, Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate is employed in multi-step synthesis pathways leading to critical drug molecules. For instance, its incorporation can contribute to the development of novel kinase inhibitors, antiviral agents, or compounds with neurological activity. Understanding its reactivity and stability, such as its predicted boiling point of 436.4±37.0 °C, is vital for process chemists to design efficient and scalable manufacturing routes.

When sourcing this intermediate, pharmaceutical companies often look towards established chemical manufacturers, particularly those in China, who can offer competitive pricing without compromising on quality. Buying directly from a reputable manufacturer ensures better control over the supply chain and potentially better pricing. The ability to procure a consistent supply of CAS 221675-35-0 is critical for maintaining uninterrupted production schedules, thus avoiding costly delays.

Furthermore, suppliers should be able to provide comprehensive documentation, including detailed Certificates of Analysis (CoA) and Safety Data Sheets (SDS). The chemical's storage recommendations, such as keeping it sealed and dry at room temperature, are also important to follow to preserve its quality. Engaging with a manufacturer that offers robust technical support can also be beneficial, assisting in the integration of this intermediate into existing manufacturing processes.

In conclusion, Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate is an indispensable pharmaceutical intermediate for API manufacturing. Its high purity and unique chemical structure enable the synthesis of advanced therapeutic agents. Pharmaceutical businesses looking to buy this essential compound should prioritize working with trusted suppliers and manufacturers who can guarantee consistent quality, reliable supply, and competitive pricing to support their critical production needs.