Expert Insights: The Chemical Properties and Uses of Fmoc-Dab(Boc)-OH
Understanding the intricate chemical properties of key building blocks is fundamental for successful peptide synthesis and related research. Fmoc-Dab(Boc)-OH, scientifically identified as N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-t-butyloxycarbonyl-L-2,4-diaminobutyric acid, is a prime example of such a compound. Its structure and protected functional groups make it exceptionally versatile for advanced synthetic strategies.
The molecular structure of Fmoc-Dab(Boc)-OH features a 2,4-diaminobutyric acid backbone. The alpha-amino group is protected by the Fluorenylmethyloxycarbonyl (Fmoc) group, a common protecting group in peptide synthesis that is typically removed under mild basic conditions. Simultaneously, the gamma-amino group is protected by the tert-butyloxycarbonyl (Boc) group, which is acid-labile. This differential protection strategy, known as orthogonality, allows chemists to selectively manipulate each amino group at different stages of synthesis. For example, after coupling Fmoc-Dab(Boc)-OH into a growing peptide chain and removing the Fmoc group, the free gamma-amino group can be further modified before the Boc group is eventually cleaved during final deprotection.
Researchers aiming to buy Fmoc-Dab(Boc)-OH often require detailed technical specifications to ensure it meets their project's demands. NINGBO INNO PHARMCHEM CO.,LTD., a leading Fmoc-Dab(Boc)-OH manufacturer in China, provides these critical details, including molecular weight (440.5 g/mol), molecular formula (C24H28N2O6), and assurance of high purity, typically exceeding 98%. These specifications are crucial for anyone seeking high purity Fmoc-Dab(Boc)-OH for peptide synthesis.
The applications of Fmoc-Dab(Boc)-OH extend beyond standard peptide synthesis. It is frequently used in the creation of peptide-drug conjugates (PDCs), where the diaminobutyric acid residue serves as a linker for attaching therapeutic payloads. Its utility in solid-phase synthesis makes it a preferred choice for creating libraries of peptides for screening in drug discovery programs. As a trusted CAS 125238-99-5 supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent availability and quality for these advanced applications.
To procure this essential compound, consider NINGBO INNO PHARMCHEM CO.,LTD. We offer competitive Fmoc-Dab(Boc)-OH prices and are equipped to handle Fmoc-Dab(Boc)-OH bulk purchase inquiries. We invite researchers and procurement specialists to contact us for a quote and to discuss how our high-quality chemical reagents can support your scientific endeavors.
Perspectives & Insights
Nano Explorer 01
“This differential protection strategy, known as orthogonality, allows chemists to selectively manipulate each amino group at different stages of synthesis.”
Data Catalyst One
“For example, after coupling Fmoc-Dab(Boc)-OH into a growing peptide chain and removing the Fmoc group, the free gamma-amino group can be further modified before the Boc group is eventually cleaved during final deprotection.”
Chem Thinker Labs
“Researchers aiming to buy Fmoc-Dab(Boc)-OH often require detailed technical specifications to ensure it meets their project's demands.”