The Role of Fmoc-Dab(Boc)-OH in Advanced Peptide Synthesis
Peptide synthesis is a cornerstone of modern drug discovery and development, enabling the creation of complex therapeutic agents and research tools. At the heart of this process are protected amino acids, which serve as the fundamental building blocks. Among these, Fmoc-Dab(Boc)-OH, also known as N-alpha-Fmoc-N-gamma-Boc-L-2,4-diaminobutyric acid, is particularly valuable due to its unique diamine structure, allowing for diverse peptide modifications and conjugations.
Fmoc-Dab(Boc)-OH is widely used in solid-phase peptide synthesis (SPPS) due to the orthogonality of its protecting groups. The Fmoc group on the alpha-amino position is acid-labile, while the Boc group on the gamma-amino position is base-labile. This differential protection allows for selective deprotection and further functionalization at the gamma-amino group during or after peptide chain elongation. This capability is essential when synthesizing peptides that require side-chain modifications, such as conjugation with labels, cytotoxic drugs for antibody-drug conjugates (ADCs), or polymers for improved pharmacokinetics.
Researchers looking to buy Fmoc-Dab(Boc)-OH often seek out suppliers who guarantee high purity and consistent quality. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated Fmoc-Dab(Boc)-OH manufacturer in China, ensures that its product meets stringent specifications. This commitment translates to reliable performance in complex synthesis protocols, minimizing the risk of failed synthesis batches and saving valuable time and resources. For those needing to buy high purity Fmoc-Dab(Boc)-OH for peptide synthesis, our product is an excellent choice.
The availability of Fmoc-Dab(Boc)-OH in various pack sizes, from grams for research to kilograms for bulk production, is also a significant consideration. When comparing Fmoc-Dab(Boc)-OH prices, it's important to consider not just the per-unit cost but also the overall value proposition, which includes product quality, supplier reliability, and customer support. NINGBO INNO PHARMCHEM CO.,LTD. offers competitive Fmoc-Dab(Boc)-OH pricing and is a trusted CAS 114360-56-4 supplier dedicated to supporting your research endeavors.
In summary, the strategic use of Fmoc-Dab(Boc)-OH in peptide synthesis unlocks pathways to novel therapeutics and research tools. As a leading supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides the high-quality materials and reliable service that researchers and manufacturers depend on. Contact us today to inquire about purchasing Fmoc-Dab(Boc)-OH and to get a quote for your specific needs.
Perspectives & Insights
Bio Analyst 88
“The Fmoc group on the alpha-amino position is acid-labile, while the Boc group on the gamma-amino position is base-labile.”
Nano Seeker Pro
“This differential protection allows for selective deprotection and further functionalization at the gamma-amino group during or after peptide chain elongation.”
Data Reader 7
“This capability is essential when synthesizing peptides that require side-chain modifications, such as conjugation with labels, cytotoxic drugs for antibody-drug conjugates (ADCs), or polymers for improved pharmacokinetics.”