The world of organic synthesis is constantly seeking novel building blocks that offer versatility and enable the creation of complex molecular structures. 4-(4-Bromo-3-formylphenoxy)benzonitrile (CAS: 906673-54-9) stands out as a particularly valuable intermediate for chemists engaged in cutting-edge research and development. Its unique combination of functional groups provides multiple avenues for sophisticated chemical transformations, making it a sought-after compound for manufacturers and R&D professionals alike.

Chemical Reactivity and Functional Groups:

At its core, 4-(4-Bromo-3-formylphenoxy)benzonitrile possesses several key reactive sites: the aryl bromide, the aldehyde (formyl) group, and the nitrile group. The aryl bromide moiety is susceptible to various cross-coupling reactions, such as Suzuki, Heck, or Sonogashira couplings, allowing for the introduction of diverse carbon-based substituents. The aldehyde group can participate in nucleophilic additions, Wittig reactions, reductive aminations, and oxidation/reduction reactions, offering pathways to alcohols, amines, carboxylic acids, and other functional groups. The nitrile group, while generally less reactive, can be hydrolyzed to a carboxylic acid, reduced to an amine, or involved in cycloaddition reactions, further expanding its synthetic utility.

Synthetic Pathways and Applications:

The primary application driving the demand for this compound is its use as an intermediate in the pharmaceutical industry, particularly in the synthesis of Crisaborole. However, its utility extends far beyond this single application. Researchers often employ it in the synthesis of:

  • Heterocyclic compounds: The formyl and nitrile groups can be strategically utilized to construct various nitrogen-containing heterocycles, which are prevalent in many biologically active molecules.
  • Biaryl and Aryl-Alkyl compounds: Through palladium-catalyzed cross-coupling reactions at the aryl bromide position, complex biaryl structures or aryl-alkyl chains can be efficiently assembled.
  • Scaffolds for Drug Discovery: Its rigid structure and multiple functionalization points make it an excellent starting material for building diverse chemical libraries for drug screening.

For those looking to buy 4-(4-Bromo-3-formylphenoxy)benzonitrile for their research, securing a high-purity grade is critical. Impurities can significantly affect reaction yields and the purity of downstream products. Therefore, working with reputable manufacturers and suppliers who provide detailed analytical data is paramount.

Sourcing Strategies for Buyers:

When sourcing 4-(4-Bromo-3-formylphenoxy)benzonitrile, consider a strategic approach:

  1. Identify Reliable Manufacturers: Look for chemical companies with a proven track record in producing fine chemicals and pharmaceutical intermediates. China-based manufacturers often offer competitive pricing for bulk orders.
  2. Request Comprehensive Documentation: Always ask for a Certificate of Analysis (CoA) detailing purity, identification, and impurity profiles. Safety Data Sheets (SDS) are also essential.
  3. Compare Quotes: Obtain multiple price quotes from various suppliers to ensure you are getting the best value. Factor in shipping costs and lead times.
  4. Consider Custom Synthesis: If specific modifications or very high purity is required, some suppliers may offer custom synthesis services.

The ability to purchase 4-(4-Bromo-3-formylphenoxy)benzonitrile from a trusted supplier ensures that your organic synthesis projects proceed smoothly and efficiently. Its rich chemical reactivity makes it an indispensable tool for chemists aiming to push the boundaries of molecular design.