The pharmaceutical industry's constant drive for innovation relies heavily on a consistent supply of high-quality chemical intermediates. Among these, heterocyclic compounds like 2-Fluoro-5-nitropyridine (CAS 456-24-6) play a crucial role. This article provides an in-depth look at this important compound, exploring its chemical nature, synthetic applications, and its significance in the broader chemical market, from the perspective of a leading manufacturer and supplier.

Chemical Identity and Properties

2-Fluoro-5-nitropyridine is a fluorinated pyridine derivative with the molecular formula C5H3FN2O2 and a molecular weight of approximately 142.09. It is typically supplied as a White Powder, indicating a relatively pure and solid form at room temperature. Its melting point, generally reported in the range of 142-144°C, is a key parameter for identification and purity assessment. The presence of both a fluorine atom and a nitro group on the pyridine ring imparts specific electronic and reactive characteristics, making it a valuable synthon in organic chemistry.

Synthetic Utility and Applications

The primary application of 2-Fluoro-5-nitropyridine is as a versatile intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Its structure allows for various chemical transformations:

  • Nucleophilic Aromatic Substitution (SNAr): The fluorine atom at the 2-position can be readily displaced by various nucleophiles, allowing for the introduction of diverse functional groups. This is a critical step in building complex pharmaceutical molecules.
  • Nitro Group Reduction: The nitro group at the 5-position can be reduced to an amine group, which then serves as a point for further derivatization, such as amidation, alkylation, or formation of heterocycles.

These reactions are fundamental in drug discovery and development, enabling chemists to construct molecules with desired pharmacological activities. Therefore, ensuring a high purity of 2-Fluoro-5-nitropyridine (e.g., ≥99.0%) is vital for achieving reproducible results and efficient synthetic pathways.

Market Significance and Sourcing Considerations

As a key building block, the market for 2-Fluoro-5-nitropyridine is closely tied to the growth of the pharmaceutical industry. Businesses looking to purchase this intermediate should partner with reputable manufacturers and suppliers who can guarantee consistent quality and a stable supply chain. When evaluating a supplier, consider factors such as:

  • Purity Verification: Always request a Certificate of Analysis (CoA).
  • Manufacturing Standards: Compliance with quality management systems.
  • Production Capacity: Ability to meet volume requirements.
  • Technical Support: Assistance with product usage and specifications.

For companies seeking to buy 2-Fluoro-5-nitropyridine, working with experienced manufacturers and suppliers who understand the rigorous demands of the pharmaceutical sector is crucial. We, as a dedicated provider, are committed to meeting these standards, offering high-quality 2-Fluoro-5-nitropyridine to support your critical research and manufacturing needs.

The strategic importance of intermediates like 2-Fluoro-5-nitropyridine cannot be overstated. By understanding its chemical properties and market role, and by securing a dependable supply source, pharmaceutical and chemical companies can accelerate their R&D pipelines and bring essential new products to market.