Exploring the Chemical Structure of DSPE-mPEG2000 for Advanced Nanomedicine
Understanding the intricate chemical structure of DSPE-mPEG2000 (Sodium Salt) is fundamental to appreciating its diverse applications in advanced nanomedicine and cutting-edge drug delivery. NINGBO INNO PHARMCHEM CO.,LTD., a leading supplier in China, provides this high-quality PEGylated phospholipid, enabling researchers to leverage its unique molecular architecture for groundbreaking pharmaceutical innovations.
At its core, DSPE-mPEG2000 is a conjugate of distearoylphosphatidylethanolamine (DSPE) and methoxypolyethylene glycol (mPEG). The DSPE component serves as a lipid anchor, a saturated phospholipid with two stearic acid chains. This hydrophobic tail allows the molecule to readily insert into the lipid bilayers of liposomes, lipid nanoparticles (LNPs), and micelles. The critical feature is the attachment of a PEG chain, specifically a methoxy-terminated PEG with an average molecular weight of 2000 Daltons. This PEG chain extends outwards from the lipid core.
The presence of the PEG chain confers several significant advantages. Firstly, its hydrophilic nature imparts stealth properties. This means the PEGylated surface creates a barrier that minimizes protein adsorption and immune cell recognition, thus significantly extending the in vivo circulation time of the associated nanocarriers. Secondly, the PEG chain can modulate particle size and surface charge, influencing biodistribution and cellular uptake. The methoxy termination prevents further reaction or cross-linking of the PEG chain itself, ensuring a stable and well-defined conjugate.
The sodium salt form of this compound further enhances its utility, often improving solubility and ease of handling in aqueous formulations. For those looking to buy DSPE-mPEG2000, its well-defined structure is a testament to its reliability in creating predictable and reproducible nanoparticle systems. Researchers can harness the specific properties of the DSPE anchor and the PEG chain for diverse applications, from encapsulating hydrophobic drugs to conjugating targeting moieties.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying DSPE-mPEG2000 (Sodium Salt) with stringent purity standards. As a reputable manufacturer in China, we understand that the success of advanced nanomedicine relies on the quality of its building blocks. Explore the potential of this critical lipid by inquiring about our competitive price and experiencing the difference quality makes in your research.
At its core, DSPE-mPEG2000 is a conjugate of distearoylphosphatidylethanolamine (DSPE) and methoxypolyethylene glycol (mPEG). The DSPE component serves as a lipid anchor, a saturated phospholipid with two stearic acid chains. This hydrophobic tail allows the molecule to readily insert into the lipid bilayers of liposomes, lipid nanoparticles (LNPs), and micelles. The critical feature is the attachment of a PEG chain, specifically a methoxy-terminated PEG with an average molecular weight of 2000 Daltons. This PEG chain extends outwards from the lipid core.
The presence of the PEG chain confers several significant advantages. Firstly, its hydrophilic nature imparts stealth properties. This means the PEGylated surface creates a barrier that minimizes protein adsorption and immune cell recognition, thus significantly extending the in vivo circulation time of the associated nanocarriers. Secondly, the PEG chain can modulate particle size and surface charge, influencing biodistribution and cellular uptake. The methoxy termination prevents further reaction or cross-linking of the PEG chain itself, ensuring a stable and well-defined conjugate.
The sodium salt form of this compound further enhances its utility, often improving solubility and ease of handling in aqueous formulations. For those looking to buy DSPE-mPEG2000, its well-defined structure is a testament to its reliability in creating predictable and reproducible nanoparticle systems. Researchers can harness the specific properties of the DSPE anchor and the PEG chain for diverse applications, from encapsulating hydrophobic drugs to conjugating targeting moieties.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying DSPE-mPEG2000 (Sodium Salt) with stringent purity standards. As a reputable manufacturer in China, we understand that the success of advanced nanomedicine relies on the quality of its building blocks. Explore the potential of this critical lipid by inquiring about our competitive price and experiencing the difference quality makes in your research.
Perspectives & Insights
Molecule Vision 7
“For those looking to buy DSPE-mPEG2000, its well-defined structure is a testament to its reliability in creating predictable and reproducible nanoparticle systems.”
Alpha Origin 24
“Researchers can harness the specific properties of the DSPE anchor and the PEG chain for diverse applications, from encapsulating hydrophobic drugs to conjugating targeting moieties.”
Future Analyst X
“is dedicated to supplying DSPE-mPEG2000 (Sodium Salt) with stringent purity standards.”