The Role of DSPE-mPEG2000 (Sodium Salt) in Stealth Liposome Technology
The efficacy of liposomal drug delivery systems has been significantly advanced by the development of 'stealth' liposome technology. A cornerstone ingredient enabling this breakthrough is DSPE-mPEG2000 (Sodium Salt), offered by NINGBO INNO PHARMCHEM CO.,LTD., a trusted supplier in China. This advanced phospholipid is instrumental in creating liposomes that evade rapid clearance from the body, thereby improving their therapeutic performance.
Traditional liposomes, while effective carriers, often suffer from rapid clearance from the bloodstream due to recognition by the immune system. This limits their circulation time and, consequently, their ability to reach target sites. Stealth liposomes overcome this challenge through the incorporation of hydrophilic polymers, most commonly polyethylene glycol (PEG), onto their surface. DSPE-mPEG2000 (Sodium Salt) is a prime example of a phospholipid-PEG conjugate perfectly suited for this purpose.
The DSPE component of DSPE-mPEG2000 acts as an anchor, embedding itself within the liposome bilayer. This anchors the PEG chains firmly to the liposome surface. The attached methoxypolyethylene glycol (mPEG) chains then form a dense hydration layer around the liposome. This hydrated layer effectively shields the liposome from interacting with serum proteins and immune cells. This 'stealth' effect dramatically increases the liposome's circulation half-life, allowing for prolonged systemic exposure and enhanced opportunities for passive targeting to areas with leaky vasculature, such as tumors.
Researchers seeking to buy high-quality materials for advanced liposome formulations will find DSPE-mPEG2000 (Sodium Salt) indispensable. Its consistent quality and precise molecular weight ensure predictable performance, crucial for reproducible drug delivery. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, is committed to providing the essential building blocks for next-generation therapeutics. Explore the advantages of stealth liposome technology by inquiring about our competitive price for DSPE-mPEG2000 (Sodium Salt) and elevate your drug delivery research.
Traditional liposomes, while effective carriers, often suffer from rapid clearance from the bloodstream due to recognition by the immune system. This limits their circulation time and, consequently, their ability to reach target sites. Stealth liposomes overcome this challenge through the incorporation of hydrophilic polymers, most commonly polyethylene glycol (PEG), onto their surface. DSPE-mPEG2000 (Sodium Salt) is a prime example of a phospholipid-PEG conjugate perfectly suited for this purpose.
The DSPE component of DSPE-mPEG2000 acts as an anchor, embedding itself within the liposome bilayer. This anchors the PEG chains firmly to the liposome surface. The attached methoxypolyethylene glycol (mPEG) chains then form a dense hydration layer around the liposome. This hydrated layer effectively shields the liposome from interacting with serum proteins and immune cells. This 'stealth' effect dramatically increases the liposome's circulation half-life, allowing for prolonged systemic exposure and enhanced opportunities for passive targeting to areas with leaky vasculature, such as tumors.
Researchers seeking to buy high-quality materials for advanced liposome formulations will find DSPE-mPEG2000 (Sodium Salt) indispensable. Its consistent quality and precise molecular weight ensure predictable performance, crucial for reproducible drug delivery. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, is committed to providing the essential building blocks for next-generation therapeutics. Explore the advantages of stealth liposome technology by inquiring about our competitive price for DSPE-mPEG2000 (Sodium Salt) and elevate your drug delivery research.
Perspectives & Insights
Core Pioneer 24
“, as a leading manufacturer in China, is committed to providing the essential building blocks for next-generation therapeutics.”
Silicon Explorer X
“Explore the advantages of stealth liposome technology by inquiring about our competitive price for DSPE-mPEG2000 (Sodium Salt) and elevate your drug delivery research.”
Quantum Catalyst AI
“The efficacy of liposomal drug delivery systems has been significantly advanced by the development of 'stealth' liposome technology.”