In the dynamic field of organic synthesis and medicinal chemistry, specialized building blocks are paramount for groundbreaking research. Among these, indole derivatives hold a significant position due to their presence in numerous biologically active compounds. Specifically, 5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) stands out as a highly versatile intermediate. This article aims to delve into its synthesis, explore its multifaceted applications, and guide researchers and procurement managers on how to efficiently source this critical compound from reputable manufacturers.

Understanding 5-Bromoindole-2-carboxylic Acid

5-Bromoindole-2-carboxylic acid is characterized by a bromine atom at the 5th position of the indole ring and a carboxylic acid group at the 2nd position. This structural arrangement imparts unique reactivity, making it an indispensable tool for chemists. Its physical properties typically include a white to light yellow appearance, and it is generally stable under recommended storage conditions, often stored at -20°C. Its melting point is generally reported in the range of 280-294°C, indicating its robust nature.

Synthesis Pathways for Efficiency

The efficient synthesis of 5-Bromoindole-2-carboxylic acid is crucial for its widespread use. A common and effective method involves the hydrolysis of its corresponding ester, such as ethyl 5-bromoindole-2-carboxylate. The process typically involves dissolving the ester in a solvent mixture, heating to reflux, and then acidifying the solution to precipitate the desired carboxylic acid. Yields are often high, and the product can be further purified through recrystallization. For R&D professionals looking to buy this compound, understanding its synthesis helps in appreciating the quality and cost factors from a manufacturer. Manufacturers often optimize these routes for scalability and cost-effectiveness.

Applications Across Industries

The utility of 5-Bromoindole-2-carboxylic acid spans several key areas:

  • Pharmaceutical Intermediates: It serves as a foundational element in the synthesis of numerous drug candidates. Its indole core is prevalent in compounds targeting neurological disorders, inflammatory conditions, and cancer. For instance, it has been used in studies for MMP-13 inhibitors for arthritic diseases and as a precursor for indolyl ethanones that act as indoleamine 2,3-dioxygenase inhibitors.
  • Medicinal Chemistry Research: Researchers utilize this compound to explore new chemical probes, develop dual PPAR agonists, and synthesize tubulin polymerization inhibitors, all critical in advancing drug discovery pipelines.
  • Agrochemicals: The indole structure also finds relevance in agrochemical development, contributing to the creation of more effective crop protection agents.
  • Material Science: Its electronic properties are being investigated for advanced materials, including organic semiconductors.

When sourcing this chemical, consider the purity and CAS number (7254-19-5) to ensure you are obtaining the correct material for your specific research needs. Reliable manufacturers will provide detailed specifications and certificates of analysis.

Sourcing from Trusted Manufacturers

For procurement managers and research scientists, identifying reliable suppliers is key. Leading manufacturers based in China and globally offer 5-Bromoindole-2-carboxylic acid with guaranteed quality and competitive pricing. When you seek to buy this product, look for suppliers who can provide:

  • High Purity (e.g., ≥ 98%): Essential for reproducible research outcomes.
  • Consistent Supply: Ensuring your projects are not interrupted.
  • Technical Support and Documentation: Including SDS and COA.
  • Competitive Pricing and Bulk Discounts: To manage R&D budgets effectively.

Engaging with a trusted chemical supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures you receive a quality product essential for your synthetic chemistry projects. Explore our offerings and request a quote for your next research endeavor.