The quest for novel and effective pharmaceuticals relies heavily on a deep understanding of the chemical building blocks used in their synthesis. Among these, chiral intermediates with specific structural motifs are invaluable. This article focuses on (1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one (CAS 79200-56-9), often referred to as Vince lactam, a compound with significant utility in the pharmaceutical sector.

Vince lactam, a bicyclic γ-lactam, is characterized by its off-white to beige crystalline powder appearance. Key chemical properties include a melting point in the range of 94-97°C and a molecular weight of 109.13 g/mol. Its defined stereochemistry, (1R,4S), is critical for its function as a chiral synthon, enabling the precise construction of complex drug molecules. The compound's structure, containing a lactam ring fused to a bicyclic system with an alkene, offers multiple points for chemical modification and derivatization.

The synthesis of Vince lactam often starts from readily available precursors, with a significant focus on achieving high enantiomeric purity. Numerous research papers detail various synthesis strategies, including enzymatic resolutions using specific lactamases, highlighting the scientific interest in optimizing its production. Its utility extends to being a precursor for various advanced compounds. For instance, it's crucial in the synthesis pathway for Amino-peramivir, a potent neuraminidase inhibitor, and also finds application in creating carbocyclic sugar amines and analogues relevant to antiviral research.

For professionals seeking to buy or procure this intermediate, understanding its applications is key. Pharmaceutical companies and research institutions rely on such compounds for drug discovery, particularly in areas like antiviral therapy and potentially in modulating neurotransmitter systems through its derivatives. Identifying a reputable supplier that can guarantee the purity and stereochemical integrity of (1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one is paramount. Companies that act as both manufacturers and suppliers often offer the best combination of quality control and competitive pricing, especially when sourcing from established chemical hubs.

In summary, Vince lactam is more than just a chemical intermediate; it is a key enabler of pharmaceutical innovation. Its detailed chemical properties and diverse applications underscore its importance for researchers and developers in the pharmaceutical industry.