The field of organic synthesis is constantly seeking versatile building blocks that can facilitate the creation of complex molecules. Ethyl 5-Bromobenzofuran-2-Carboxylate (CAS: 84102-69-2) is a prime example of such a compound, offering a unique combination of a benzofuran core and reactive functionalities that are highly valued in chemical research and development.

This compound, typically found as a light yellow solid powder, is distinguished by its molecular formula C11H9BrO3 and a molecular weight of approximately 269.09 g/mol. Its key structural features include a benzofuran heterocyclic system, an ester group at the 2-position, and a bromine atom at the 5-position. The bromine atom, in particular, is a crucial reactive handle. It readily participates in a wide array of metal-catalyzed cross-coupling reactions, including Suzuki, Stille, and Heck couplings. These reactions are fundamental for constructing new carbon-carbon bonds, enabling chemists to synthesize more elaborate molecular frameworks.

The ester moiety also offers avenues for chemical manipulation, such as hydrolysis to the corresponding carboxylic acid, reduction to an alcohol, or transesterification. This bifunctionality makes Ethyl 5-Bromobenzofuran-2-Carboxylate an attractive starting material for chemists aiming to introduce the benzofuran substructure into various target molecules.

Its applications extend across several domains, with a notable presence in pharmaceutical synthesis. As an intermediate, it is employed in the creation of compounds like Veratrazodone hydrochloride. Researchers in medicinal chemistry often look for this specific compound, searching for 'buy Ethyl 5-Bromobenzofuran-2-Carboxylate' to source it for their drug discovery programs. The high purity (≥99%) ensures that reactions proceed cleanly, minimizing side products and facilitating the isolation of desired compounds.

For professionals in the chemical industry, understanding the synthesis and sourcing of such intermediates is vital. Manufacturers in China are often leading suppliers, offering competitive pricing and reliable quality. When procuring this chemical, it is advisable to look for a manufacturer that provides detailed specifications, including melting point (60-62°C) and other physical properties, along with safety data. This due diligence ensures that the material meets the stringent requirements of research and industrial applications.

In summary, Ethyl 5-Bromobenzofuran-2-Carboxylate is a valuable synthetic tool due to its inherent chemical reactivity and its role as a versatile building block. Its importance in organic synthesis, particularly for pharmaceutical research, highlights the need for readily available, high-purity sources. Exploring reputable chemical suppliers and manufacturers will ensure access to this essential compound for ongoing scientific advancements.