The benzofuran scaffold is a foundational structure in organic chemistry, recognized for its prevalence in natural products and its versatility in synthetic applications, particularly within medicinal chemistry. Ethyl 5-Bromobenzofuran-2-Carboxylate (CAS: 84102-69-2) stands as a representative example of a functionalized benzofuran derivative that is instrumental in advancing research and development.

This specific compound, characterized as a light yellow solid powder, offers a unique combination of a benzofuran core substituted with a bromine atom at the 5-position and an ethyl carboxylate group at the 2-position. These structural features impart specific reactivity patterns that are highly valuable. The bromine atom, for instance, serves as an excellent leaving group in various metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Heck couplings. This capability allows for the efficient construction of carbon-carbon bonds, enabling the synthesis of complex molecular architectures.

In the realm of pharmaceutical development, benzofuran derivatives are often explored for their diverse biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. Ethyl 5-Bromobenzofuran-2-Carboxylate plays a critical role as an intermediate in the synthesis of such bioactive compounds. Its use in the preparation of Veratrazodone hydrochloride is a notable example, highlighting its importance in the drug discovery pipeline. Researchers actively seek this compound when investigating new therapeutic agents, often searching for 'buy Ethyl 5-Bromobenzofuran-2-Carboxylate' to source from reliable manufacturers.

The physical and chemical properties, such as its melting point of 60-62°C and high purity (≥99%), ensure its suitability for precise chemical transformations. When considering its procurement, understanding these specifications and sourcing from reputable 'chemical manufacturers' is key. The global market offers numerous suppliers, with many businesses opting for Chinese manufacturers due to their specialized capabilities and competitive pricing for such intermediates.

The historical context of benzofuran chemistry reveals a continuous evolution of synthetic methodologies, from early cyclization reactions to modern transition-metal-catalyzed processes. Ethyl 5-Bromobenzofuran-2-Carboxylate benefits from these advancements, allowing for efficient synthesis and widespread availability. As research progresses, the demand for such versatile building blocks is expected to grow, reinforcing the importance of a stable supply chain for these critical organic compounds.

In conclusion, Ethyl 5-Bromobenzofuran-2-Carboxylate exemplifies the significance of functionalized benzofuran derivatives in modern chemistry. Its utility in organic synthesis and pharmaceutical research makes it a sought-after intermediate. For professionals in the field, understanding its properties and identifying reliable suppliers is crucial for driving innovation and achieving successful research outcomes.