Fungal infections of the skin present a persistent challenge in healthcare, necessitating potent and well-tolerated treatments. Flutrimazole, an imidazole antifungal agent with the CAS number 119006-77-8, has emerged as a significant therapeutic option due to its broad-spectrum efficacy and beneficial properties. This article explores the key aspects of Flutrimazole, from its chemical profile to its applications in dermatological treatment and its role within the pharmaceutical supply chain.

Flutrimazole is characterized by its molecular structure, which includes an imidazole ring. Its molecular formula is C22H16F2N2, and it has a molecular weight of approximately 346.37 g/mol. Typically appearing as a white powder, Flutrimazole exhibits limited solubility in water but is soluble in various organic solvents, which facilitates its incorporation into topical pharmaceutical formulations. This solubility profile is critical for ensuring effective delivery to the affected skin areas for treating antifungal skin infections.

The primary mechanism of action for Flutrimazole involves the inhibition of fungal lanosterol 14α-demethylase. This enzyme is essential for the biosynthesis of ergosterol, a vital structural component of fungal cell membranes. By disrupting ergosterol synthesis, Flutrimazole compromises the integrity and function of these membranes, leading to the death of fungal cells. This precise mechanism of action makes Flutrimazole highly effective against a wide range of fungal pathogens, including dermatophytes, yeasts, and filamentous fungi. The compound is particularly valued for its topical application in treating superficial mycoses of the skin.

In addition to its antifungal potency, Flutrimazole also exhibits anti-inflammatory properties, which can help alleviate symptoms such as redness and itching often associated with fungal infections. Clinical studies report good local and systemic tolerance, enhancing its suitability for prolonged treatment regimens. For the pharmaceutical industry, Flutrimazole is also recognized as a valuable pharmaceutical intermediate, essential for the synthesis of various active pharmaceutical ingredients. NINGBO INNO PHARMCHEM CO., LTD. is committed to providing high-quality chemicals that meet the stringent requirements of pharmaceutical manufacturing. Access to reliable sources of compounds like Flutrimazole CAS 119006-77-8 is crucial for continuous innovation in antifungal therapy.