The field of bioconjugation, which involves the covalent linking of biomolecules to synthetic molecules, is revolutionizing medicine and diagnostics. At the heart of many advanced bioconjugation strategies is the availability of precisely engineered chemical intermediates. Fmoc-4-carboxymethyl-piperazine (CAS: 180576-05-0) is one such compound, offering a unique combination of a protected amine and a reactive carboxylic acid group, making it a highly sought-after reagent for researchers in biotechnology and pharmaceutical sciences.

Fmoc-4-carboxymethyl-piperazine, typically supplied as a white to off-white powder with a purity of ≥98% (HPLC), is particularly valuable for its dual functionality. The Fmoc group provides temporary protection for the piperazine nitrogen during peptide or conjugate assembly, allowing for orthogonal chemical reactions. Following deprotection, the exposed secondary amine can be further modified. Crucially, the terminal carboxymethyl group offers a straightforward site for esterification, amidation, or other coupling reactions, enabling the attachment of peptides, proteins, antibodies, or imaging agents.

For companies involved in developing targeted drug delivery systems or diagnostic assays, securing a consistent supply of high-quality Fmoc-4-carboxymethyl-piperazine is essential. This requires partnering with reliable manufacturers and suppliers, particularly those with a strong track record in producing complex organic molecules. When evaluating suppliers, consider their ability to provide detailed product specifications, Certificates of Analysis (CoA), and responsive customer service. Understanding the price of Fmoc-4-carboxymethyl-piperazine is also key for budgeting and cost management in research projects.

The versatility of Fmoc-4-carboxymethyl-piperazine in bioconjugation is evident in its application for:

  • Antibody-Drug Conjugates (ADCs): Linking cytotoxic drugs to monoclonal antibodies for targeted cancer therapy.
  • Diagnostic Probes: Attaching fluorescent dyes or radioisotopes to biomolecules for imaging and detection.
  • Peptide-based Therapeutics: Incorporating modified peptides into complex delivery systems or conjugation strategies.
  • Surface Functionalization: Immobilizing biomolecules onto surfaces for biosensors or diagnostic microarrays.

The ability to easily purchase Fmoc-4-carboxymethyl-piperazine from a reputable manufacturer, potentially with competitive pricing options for bulk orders, significantly streamlines research workflows. As a dedicated manufacturer and supplier, we understand the critical role this intermediate plays and are committed to providing the quality and reliability that the bioconjugation field demands. Explore our offerings to secure this vital component for your next breakthrough.