The field of custom peptide synthesis is critical for advancements in biotechnology, pharmaceuticals, and academic research. It enables scientists to create bespoke peptide sequences with specific functionalities, essential for therapeutic development, diagnostic tools, and fundamental biological studies. A key component in achieving such precision is the availability of specialized unnatural amino acids, including Fmoc-D-2-Bromophenylalanine (CAS: 220497-79-0). Understanding its role and how to source it effectively is paramount for project success.

Fmoc-D-2-Bromophenylalanine is a derivative of phenylalanine, featuring the Fmoc (9-fluorenylmethoxycarbonyl) protecting group. This protecting group is the hallmark of the Fmoc strategy in Solid-Phase Peptide Synthesis (SPPS), a dominant technique in custom peptide production. The Fmoc group provides facile protection of the alpha-amino group and can be removed under mild basic conditions, such as treatment with piperidine. This mild cleavage is crucial for the integrity of growing peptide chains, especially when they incorporate sensitive amino acid side chains or are attached to specialized resins. The resulting free amine is then ready for coupling with the next Fmoc-protected amino acid, allowing for the step-wise construction of the desired peptide sequence.

What sets Fmoc-D-2-Bromophenylalanine apart is the bromine substituent on the phenyl ring. This halogen atom introduces a point of reactivity that is highly sought after in drug development and medicinal chemistry. The bromine can be leveraged in various cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), allowing for the introduction of diverse chemical groups, the creation of complex side chains, or the conjugation of the peptide to other molecules. This versatility is invaluable for fine-tuning the pharmacological properties of peptide-based drug candidates, such as their stability, bioavailability, or targeted delivery. For researchers aiming to buy this compound for their custom synthesis projects, ensuring its quality is vital.

The demand for high-purity Fmoc-D-2-Bromophenylalanine is substantial in custom peptide synthesis laboratories and pharmaceutical R&D departments. A reliable supplier ensures that this critical building block is consistently available and meets the necessary purity specifications (typically ≥97%). NINGBO INNO PHARMCHEM CO.,LTD. serves as a dedicated manufacturer and supplier, committed to providing high-quality unnatural amino acids. By offering competitive pricing for this specialized chemical, we support the economic viability of research projects, from initial discovery to scale-up.

The applications of Fmoc-D-2-Bromophenylalanine are broad, impacting several key areas of drug development. It can be used to synthesize peptide analogs with enhanced biological activity, peptides designed for specific receptor binding, or peptide-drug conjugates. Its utility also extends to the creation of peptide probes for diagnostic imaging or biochemical assays. For any custom peptide synthesis project requiring a modified phenylalanine residue with potential for further chemical derivatization, this compound is an excellent choice. Researchers seeking to purchase this reagent or request a quote are encouraged to connect with our experienced sales team to ensure they receive the most suitable materials for their work.

In summary, Fmoc-D-2-Bromophenylalanine (CAS: 220497-79-0) is an essential unnatural amino acid for advanced custom peptide synthesis and pharmaceutical drug development. Its combination of Fmoc protection and a functionalizable bromine atom makes it a powerful building block for creating novel peptide structures. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a leading manufacturer and supplier, committed to providing the high-quality materials necessary for innovation in this critical scientific field.