For procurement managers and R&D scientists in the chemical and pharmaceutical industries, the selection of suppliers for critical building blocks is a strategic decision. Fmoc-D-2-Bromophenylalanine (CAS: 220497-79-0) is one such compound, vital for advanced synthesis projects, particularly in peptide chemistry and drug discovery. Understanding the factors that influence its quality, pricing, and availability from a manufacturer’s perspective is key to making informed purchasing decisions.

Fmoc-D-2-Bromophenylalanine is an unnatural amino acid derivative, valued for its unique chemical properties. The presence of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group makes it highly compatible with Solid-Phase Peptide Synthesis (SPPS), the workhorse for constructing peptides. The Fmoc strategy relies on mild basic conditions for deprotection, allowing for precise, step-wise addition of amino acids. This method ensures minimal damage to sensitive peptide chains and is amenable to automation. The D-configuration (the 'D' in Fmoc-D-) refers to the specific stereochemistry, which is crucial for creating peptides with desired biological activities.

The defining feature of this molecule, however, is the bromine atom substituent on the phenyl ring. This halogen atom is a versatile functional handle, enabling a wide range of chemical transformations. It is particularly useful in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, or Sonogashira couplings. These reactions are fundamental in modern organic synthesis for creating new carbon-carbon bonds, allowing chemists to build complex molecular structures. In medicinal chemistry, this allows for the facile introduction of diverse functional groups, which can significantly influence a peptide’s interaction with biological targets, thereby optimizing its therapeutic potential. When considering a purchase, the integration of this bromine substituent is a key reason for its high demand.

As a manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. focuses on delivering Fmoc-D-2-Bromophenylalanine with guaranteed high purity, typically 97% or higher, verified by robust analytical methods like HPLC. The purity of such specialized reagents directly impacts the success of downstream synthesis. Impurities can lead to side reactions, reduced yields, and complications in purification, ultimately increasing project costs and timelines. Therefore, sourcing from a trusted manufacturer that prioritizes quality control is essential. We understand the importance of consistency and reliability for our clients in the research and pharmaceutical sectors.

Pricing for specialized chemical intermediates like Fmoc-D-2-Bromophenylalanine is influenced by several factors, including the complexity of synthesis, raw material costs, production scale, and market demand. As a manufacturer, we strive to offer competitive pricing, particularly for bulk orders, to support our customers’ R&D budgets. Procurement managers seeking to buy this compound should request quotes from multiple reliable suppliers. However, it is crucial to balance price with quality and supply chain reliability. Partnering with a manufacturer that provides comprehensive technical support and Certificates of Analysis (CoA) adds significant value beyond the unit price. Our commitment is to be a dependable source for your essential chemical needs.

In conclusion, Fmoc-D-2-Bromophenylalanine (CAS: 220497-79-0) is a high-value building block for sophisticated chemical syntheses. Its strategic design, featuring Fmoc protection and a reactive bromine atom, makes it indispensable for custom peptide synthesis and drug discovery. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being a premier manufacturer and supplier, ensuring that researchers and procurement specialists have access to this vital compound with the quality and consistency they require.