Fmoc-D-Arg(Pbf)-OH: A Key Intermediate in Pharmaceutical Manufacturing
The pharmaceutical industry relies on a sophisticated supply chain of specialized chemical compounds to produce life-saving medications. Among these, amino acid derivatives play an indispensable role, particularly in the synthesis of peptide-based therapeutics and complex small molecules. Fmoc-D-Arg(Pbf)-OH, identified by CAS 187618-60-6, is a prime example of such a crucial pharmaceutical intermediate. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer in China, ensures the consistent availability of this vital compound for pharmaceutical companies worldwide.
Fmoc-D-Arg(Pbf)-OH is an N-alpha-Fmoc and N-omega-Pbf protected D-arginine derivative. This specific chemical structure is engineered for efficiency and control in multistep synthesis processes. The Fmoc group is a common protecting group in peptide synthesis, easily removed under mild basic conditions. The Pbf group shields the guanidino functionality of arginine, preventing unwanted side reactions during peptide chain elongation or other synthetic transformations. This dual protection makes Fmoc-D-Arg(Pbf)-OH an ideal building block for constructing complex molecular architectures required in modern pharmaceuticals.
The significance of Fmoc-D-Arg(Pbf)-OH as a pharmaceutical intermediate is powerfully demonstrated in its application in the synthesis of etelcalcetide. Etelcalcetide is a calcimimetic agent used to treat secondary hyperparathyroidism, a common complication in patients with chronic kidney disease. The development and manufacturing of etelcalcetide necessitate the precise incorporation of specific amino acid sequences, and Fmoc-D-Arg(Pbf)-OH is a key component in achieving this structural integrity. Its availability in high purity ensures that the manufacturing process is efficient and that the final drug product meets all regulatory and quality standards.
For pharmaceutical manufacturers, sourcing reliable intermediates like Fmoc-D-Arg(Pbf)-OH is paramount. NINGBO INNO PHARMCHEM CO.,LTD. provides this essential chemical with a strong emphasis on quality and consistency. Our manufacturing capabilities allow us to supply this intermediate in quantities required for both research and large-scale production. By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your supplier for Fmoc-D-Arg(Pbf)-OH, you ensure access to a critical component that supports the successful development and production of vital pharmaceutical agents, reinforcing the supply chain for essential medicines.
Fmoc-D-Arg(Pbf)-OH is an N-alpha-Fmoc and N-omega-Pbf protected D-arginine derivative. This specific chemical structure is engineered for efficiency and control in multistep synthesis processes. The Fmoc group is a common protecting group in peptide synthesis, easily removed under mild basic conditions. The Pbf group shields the guanidino functionality of arginine, preventing unwanted side reactions during peptide chain elongation or other synthetic transformations. This dual protection makes Fmoc-D-Arg(Pbf)-OH an ideal building block for constructing complex molecular architectures required in modern pharmaceuticals.
The significance of Fmoc-D-Arg(Pbf)-OH as a pharmaceutical intermediate is powerfully demonstrated in its application in the synthesis of etelcalcetide. Etelcalcetide is a calcimimetic agent used to treat secondary hyperparathyroidism, a common complication in patients with chronic kidney disease. The development and manufacturing of etelcalcetide necessitate the precise incorporation of specific amino acid sequences, and Fmoc-D-Arg(Pbf)-OH is a key component in achieving this structural integrity. Its availability in high purity ensures that the manufacturing process is efficient and that the final drug product meets all regulatory and quality standards.
For pharmaceutical manufacturers, sourcing reliable intermediates like Fmoc-D-Arg(Pbf)-OH is paramount. NINGBO INNO PHARMCHEM CO.,LTD. provides this essential chemical with a strong emphasis on quality and consistency. Our manufacturing capabilities allow us to supply this intermediate in quantities required for both research and large-scale production. By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your supplier for Fmoc-D-Arg(Pbf)-OH, you ensure access to a critical component that supports the successful development and production of vital pharmaceutical agents, reinforcing the supply chain for essential medicines.
Perspectives & Insights
Chem Catalyst Pro
“This dual protection makes Fmoc-D-Arg(Pbf)-OH an ideal building block for constructing complex molecular architectures required in modern pharmaceuticals.”
Agile Thinker 7
“The significance of Fmoc-D-Arg(Pbf)-OH as a pharmaceutical intermediate is powerfully demonstrated in its application in the synthesis of etelcalcetide.”
Logic Spark 24
“Etelcalcetide is a calcimimetic agent used to treat secondary hyperparathyroidism, a common complication in patients with chronic kidney disease.”