The Role of CAS 187618-60-6 in Pharmaceutical Intermediate Synthesis
In the complex landscape of pharmaceutical development, the quality and reliability of chemical intermediates are paramount. CAS 187618-60-6, commonly known as Fmoc-D-Arg(Pbf)-OH, plays a pivotal role as a key pharmaceutical intermediate, underpinning the synthesis of innovative drug candidates and established therapeutics. As a premier manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. recognizes the importance of providing researchers and pharmaceutical companies with access to high-grade materials essential for their critical work.
Fmoc-D-Arg(Pbf)-OH is a specialized protected amino acid derivative. Its structure combines the D-enantiomer of arginine with two crucial protecting groups: the Fmoc group on the alpha-amino nitrogen and the Pbf group on the guanidino side chain. This dual protection strategy is fundamental to its utility in multistep organic synthesis, particularly in peptide chemistry and the production of pharmacologically active compounds. The Pbf group offers robust protection for the arginine side chain against unwanted reactions during synthesis, ensuring that the final peptide or drug molecule retains its intended structure and function. The Fmoc group facilitates its incorporation into peptide chains via standard solid-phase or solution-phase methodologies.
The application of CAS 187618-60-6 as a pharmaceutical intermediate is most notably observed in the synthesis of etelcalcetide. Etelcalcetide is a groundbreaking calcimimetic agent designed to manage secondary hyperparathyroidism in patients with chronic kidney disease. The therapeutic efficacy of etelcalcetide relies on its precise molecular structure, which is meticulously assembled using high-quality amino acid derivatives like Fmoc-D-Arg(Pbf)-OH. By incorporating this specific intermediate, manufacturers can reliably produce etelcalcetide, contributing significantly to the treatment of this chronic condition.
For companies seeking to purchase Fmoc-D-Arg(Pbf)-OH, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source. Our commitment to producing chemicals with high purity and consistent quality ensures that our clients can trust the materials used in their pharmaceutical production processes. Understanding the critical nature of these intermediates, we implement stringent quality control measures at every stage of manufacturing. This dedication to excellence allows pharmaceutical researchers and production managers to confidently procure CAS 187618-60-6, knowing they are obtaining a product that meets global standards. This focus on quality not only supports efficient synthesis but also contributes to the overall safety and efficacy of the final pharmaceutical products.
Fmoc-D-Arg(Pbf)-OH is a specialized protected amino acid derivative. Its structure combines the D-enantiomer of arginine with two crucial protecting groups: the Fmoc group on the alpha-amino nitrogen and the Pbf group on the guanidino side chain. This dual protection strategy is fundamental to its utility in multistep organic synthesis, particularly in peptide chemistry and the production of pharmacologically active compounds. The Pbf group offers robust protection for the arginine side chain against unwanted reactions during synthesis, ensuring that the final peptide or drug molecule retains its intended structure and function. The Fmoc group facilitates its incorporation into peptide chains via standard solid-phase or solution-phase methodologies.
The application of CAS 187618-60-6 as a pharmaceutical intermediate is most notably observed in the synthesis of etelcalcetide. Etelcalcetide is a groundbreaking calcimimetic agent designed to manage secondary hyperparathyroidism in patients with chronic kidney disease. The therapeutic efficacy of etelcalcetide relies on its precise molecular structure, which is meticulously assembled using high-quality amino acid derivatives like Fmoc-D-Arg(Pbf)-OH. By incorporating this specific intermediate, manufacturers can reliably produce etelcalcetide, contributing significantly to the treatment of this chronic condition.
For companies seeking to purchase Fmoc-D-Arg(Pbf)-OH, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source. Our commitment to producing chemicals with high purity and consistent quality ensures that our clients can trust the materials used in their pharmaceutical production processes. Understanding the critical nature of these intermediates, we implement stringent quality control measures at every stage of manufacturing. This dedication to excellence allows pharmaceutical researchers and production managers to confidently procure CAS 187618-60-6, knowing they are obtaining a product that meets global standards. This focus on quality not only supports efficient synthesis but also contributes to the overall safety and efficacy of the final pharmaceutical products.
Perspectives & Insights
Data Seeker X
“The Fmoc group facilitates its incorporation into peptide chains via standard solid-phase or solution-phase methodologies.”
Chem Reader AI
“The application of CAS 187618-60-6 as a pharmaceutical intermediate is most notably observed in the synthesis of etelcalcetide.”
Agile Vision 2025
“Etelcalcetide is a groundbreaking calcimimetic agent designed to manage secondary hyperparathyroidism in patients with chronic kidney disease.”