Fmoc-D-Asn(Trt)-OH: A Key Pharmaceutical Intermediate for Peptide Synthesis
The intricate process of peptide synthesis relies on a precise toolkit of chemical reagents, among which protected amino acids are fundamental. Fmoc-D-Asn(Trt)-OH, identified by its CAS number 180570-71-2, is a prime example of such a critical pharmaceutical intermediate. This article explores the characteristics and applications of Fmoc-D-Asn(Trt)-OH, highlighting its indispensability for researchers engaged in peptide synthesis and broader pharmaceutical development.
Fmoc-D-Asn(Trt)-OH is a chemically modified form of the amino acid D-asparagine. It is protected at two key positions: the alpha-amino group is shielded by the Fmoc protecting group, and the side-chain amide is protected by the trityl (Trt) group. This dual protection is essential for its role in solid-phase peptide synthesis (SPPS). The Fmoc group allows for facile deprotection under mild basic conditions, enabling sequential addition of amino acids. The trityl group on the asparagine side chain is generally stable under Fmoc deprotection conditions but can be removed during final cleavage from the resin, thus ensuring the integrity of the peptide during synthesis.
The use of the D-isomer of asparagine, as present in Fmoc-D-Asn(Trt)-OH, offers distinct advantages. Peptides incorporating D-amino acids often exhibit greater resistance to enzymatic hydrolysis by proteases, which are enzymes that break down proteins and peptides in the body. This increased stability can lead to longer half-lives for peptide-based drugs, improving their therapeutic efficacy and potentially reducing dosing frequency.
As a versatile pharmaceutical intermediate, Fmoc-D-Asn(Trt)-OH finds application in the synthesis of a wide array of peptides, including therapeutic peptides, peptide hormones, and neuropeptides. Its reliable availability from manufacturers and suppliers is crucial for both academic research and industrial-scale peptide production. A consistent supply chain ensures that research projects are not hampered by material shortages.
When sourcing Fmoc-D-Asn(Trt)-OH, attention must be paid to its quality and purity. Reputable suppliers, including those based in China, offer this intermediate with high purity levels, typically confirmed by High-Performance Liquid Chromatography (HPLC). This ensures that the building block is free from contaminants that could interfere with the delicate chemistry of peptide synthesis. The price of Fmoc-D-Asn(Trt)-OH is influenced by factors such as purity, quantity, and the manufacturer's reputation, but investing in a premium product is often cost-effective in the long run by preventing synthesis failures.
In summary, Fmoc-D-Asn(Trt)-OH (CAS 180570-71-2) is a vital protected amino acid that plays a critical role in modern peptide synthesis. Its unique protective groups and the incorporation of a D-amino acid make it an invaluable tool for researchers developing stable and potent peptide-based therapeutics. Ensuring a consistent supply of high-purity Fmoc-D-Asn(Trt)-OH is essential for the advancement of pharmaceutical research and development.
Fmoc-D-Asn(Trt)-OH is a chemically modified form of the amino acid D-asparagine. It is protected at two key positions: the alpha-amino group is shielded by the Fmoc protecting group, and the side-chain amide is protected by the trityl (Trt) group. This dual protection is essential for its role in solid-phase peptide synthesis (SPPS). The Fmoc group allows for facile deprotection under mild basic conditions, enabling sequential addition of amino acids. The trityl group on the asparagine side chain is generally stable under Fmoc deprotection conditions but can be removed during final cleavage from the resin, thus ensuring the integrity of the peptide during synthesis.
The use of the D-isomer of asparagine, as present in Fmoc-D-Asn(Trt)-OH, offers distinct advantages. Peptides incorporating D-amino acids often exhibit greater resistance to enzymatic hydrolysis by proteases, which are enzymes that break down proteins and peptides in the body. This increased stability can lead to longer half-lives for peptide-based drugs, improving their therapeutic efficacy and potentially reducing dosing frequency.
As a versatile pharmaceutical intermediate, Fmoc-D-Asn(Trt)-OH finds application in the synthesis of a wide array of peptides, including therapeutic peptides, peptide hormones, and neuropeptides. Its reliable availability from manufacturers and suppliers is crucial for both academic research and industrial-scale peptide production. A consistent supply chain ensures that research projects are not hampered by material shortages.
When sourcing Fmoc-D-Asn(Trt)-OH, attention must be paid to its quality and purity. Reputable suppliers, including those based in China, offer this intermediate with high purity levels, typically confirmed by High-Performance Liquid Chromatography (HPLC). This ensures that the building block is free from contaminants that could interfere with the delicate chemistry of peptide synthesis. The price of Fmoc-D-Asn(Trt)-OH is influenced by factors such as purity, quantity, and the manufacturer's reputation, but investing in a premium product is often cost-effective in the long run by preventing synthesis failures.
In summary, Fmoc-D-Asn(Trt)-OH (CAS 180570-71-2) is a vital protected amino acid that plays a critical role in modern peptide synthesis. Its unique protective groups and the incorporation of a D-amino acid make it an invaluable tool for researchers developing stable and potent peptide-based therapeutics. Ensuring a consistent supply of high-purity Fmoc-D-Asn(Trt)-OH is essential for the advancement of pharmaceutical research and development.
Perspectives & Insights
Nano Explorer 01
“Its unique protective groups and the incorporation of a D-amino acid make it an invaluable tool for researchers developing stable and potent peptide-based therapeutics.”
Data Catalyst One
“Ensuring a consistent supply of high-purity Fmoc-D-Asn(Trt)-OH is essential for the advancement of pharmaceutical research and development.”
Chem Thinker Labs
“The intricate process of peptide synthesis relies on a precise toolkit of chemical reagents, among which protected amino acids are fundamental.”