Sourcing High-Quality Fmoc-D-Asn(Trt)-OH for Your Peptide Synthesis Needs
The field of peptide synthesis is experiencing rapid growth, fueled by the increasing recognition of peptides as therapeutic agents and research tools. Central to this progress is the availability of high-quality protected amino acids, such as Fmoc-D-Asn(Trt)-OH (CAS 180570-71-2). This compound serves as a critical building block, and understanding its properties and sourcing is vital for researchers and manufacturers.
Fmoc-D-Asn(Trt)-OH is a protected derivative of D-asparagine, a non-essential amino acid. The defining features of this molecule are the Fmoc (9-fluorenylmethoxycarbonyl) group attached to the alpha-amino nitrogen and the trityl (Trt) group protecting the side-chain amide. These protecting groups are indispensable in solid-phase peptide synthesis (SPPS) because they prevent unwanted reactions at these sites while allowing for controlled stepwise elongation of the peptide chain. The Fmoc group is typically removed using piperidine, a mild base, enabling the next amino acid to be coupled, while the trityl group is removed during the final cleavage step.
The incorporation of D-asparagine, rather than the more common L-asparagine, is a deliberate strategy in peptide design. Peptides containing D-amino acids generally exhibit enhanced resistance to enzymatic degradation by proteases found in biological systems. This increased stability translates into longer in vivo half-lives for peptide-based drugs, leading to improved therapeutic outcomes and potentially reduced dosing frequency. Therefore, Fmoc-D-Asn(Trt)-OH is a valuable asset for developing stable and effective peptide therapeutics.
For professionals in pharmaceutical research and development, the consistent availability of high-purity Fmoc-D-Asn(Trt)-OH is a non-negotiable requirement. As a key pharmaceutical intermediate, its quality directly impacts the yield and purity of the synthesized peptide. Suppliers who rigorously test their products, often achieving ≥99% purity via HPLC, are the preferred choice. When considering purchasing this compound, it is beneficial to explore options from established manufacturers and suppliers, including those based in China, who can offer competitive pricing and reliable delivery.
The price of Fmoc-D-Asn(Trt)-OH is subject to market dynamics, including raw material costs, manufacturing processes, and supplier margins. However, the cost of such a critical intermediate should be viewed as an investment in the success of the research or production process. Prioritizing quality and reliability over the lowest price can prevent costly setbacks and ensure the integrity of the synthesized peptide.
In conclusion, Fmoc-D-Asn(Trt)-OH (CAS 180570-71-2) is a fundamental building block for advanced peptide synthesis. Its specialized protective groups and the use of the D-isomer of asparagine make it invaluable for creating stable, biologically active peptides. By understanding its role and carefully selecting suppliers, researchers can ensure the successful advancement of their peptide synthesis projects and contribute to the growing field of peptide therapeutics.
Fmoc-D-Asn(Trt)-OH is a protected derivative of D-asparagine, a non-essential amino acid. The defining features of this molecule are the Fmoc (9-fluorenylmethoxycarbonyl) group attached to the alpha-amino nitrogen and the trityl (Trt) group protecting the side-chain amide. These protecting groups are indispensable in solid-phase peptide synthesis (SPPS) because they prevent unwanted reactions at these sites while allowing for controlled stepwise elongation of the peptide chain. The Fmoc group is typically removed using piperidine, a mild base, enabling the next amino acid to be coupled, while the trityl group is removed during the final cleavage step.
The incorporation of D-asparagine, rather than the more common L-asparagine, is a deliberate strategy in peptide design. Peptides containing D-amino acids generally exhibit enhanced resistance to enzymatic degradation by proteases found in biological systems. This increased stability translates into longer in vivo half-lives for peptide-based drugs, leading to improved therapeutic outcomes and potentially reduced dosing frequency. Therefore, Fmoc-D-Asn(Trt)-OH is a valuable asset for developing stable and effective peptide therapeutics.
For professionals in pharmaceutical research and development, the consistent availability of high-purity Fmoc-D-Asn(Trt)-OH is a non-negotiable requirement. As a key pharmaceutical intermediate, its quality directly impacts the yield and purity of the synthesized peptide. Suppliers who rigorously test their products, often achieving ≥99% purity via HPLC, are the preferred choice. When considering purchasing this compound, it is beneficial to explore options from established manufacturers and suppliers, including those based in China, who can offer competitive pricing and reliable delivery.
The price of Fmoc-D-Asn(Trt)-OH is subject to market dynamics, including raw material costs, manufacturing processes, and supplier margins. However, the cost of such a critical intermediate should be viewed as an investment in the success of the research or production process. Prioritizing quality and reliability over the lowest price can prevent costly setbacks and ensure the integrity of the synthesized peptide.
In conclusion, Fmoc-D-Asn(Trt)-OH (CAS 180570-71-2) is a fundamental building block for advanced peptide synthesis. Its specialized protective groups and the use of the D-isomer of asparagine make it invaluable for creating stable, biologically active peptides. By understanding its role and carefully selecting suppliers, researchers can ensure the successful advancement of their peptide synthesis projects and contribute to the growing field of peptide therapeutics.
Perspectives & Insights
Agile Reader One
“This compound serves as a critical building block, and understanding its properties and sourcing is vital for researchers and manufacturers.”
Logic Vision Labs
“Fmoc-D-Asn(Trt)-OH is a protected derivative of D-asparagine, a non-essential amino acid.”
Molecule Origin 88
“The defining features of this molecule are the Fmoc (9-fluorenylmethoxycarbonyl) group attached to the alpha-amino nitrogen and the trityl (Trt) group protecting the side-chain amide.”