In the realm of peptide synthesis, the precise control over chemical reactivity and molecular protection is paramount. Fmoc-D-Cys(Trt)-OPfp, identified by CAS number 200395-72-8, represents a sophisticated reagent designed to meet these demanding requirements. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of this critical intermediate, providing scientists with a reliable source for high-purity materials essential for advanced peptide research and development.

The chemical structure of Fmoc-D-Cys(Trt)-OPfp integrates several key features that contribute to its efficacy in Solid Phase Peptide Synthesis (SPPS). Firstly, the N-terminal Fmoc (9-fluorenylmethoxycarbonyl) group is a standard protecting group in this methodology. Its base-labile nature allows for efficient removal using reagents like piperidine, which is compatible with many other functional groups and the solid support. Secondly, the cysteine side chain's thiol group is protected by a trityl (Trt) moiety. This bulky group effectively shields the reactive thiol during the synthesis, preventing unwanted side reactions such as disulfide bond formation. The trityl group is orthogonal to the Fmoc group, meaning it can be removed selectively under acidic conditions, typically during the final cleavage step from the resin.

The third significant feature is the pentafluorophenyl (OPfp) ester at the C-terminus. This activated ester moiety renders the carboxylic acid highly reactive towards nucleophilic attack by the free amine terminus of the growing peptide chain on the resin. This activation significantly boosts coupling efficiency, a critical parameter for achieving high yields and purity in peptide synthesis, especially for longer sequences. The D-configuration of the cysteine adds stereochemical versatility, allowing for the creation of peptides with specific three-dimensional structures and functionalities.

For researchers and procurement specialists aiming to buy Fmoc-D-Cys(Trt)-OPfp, selecting a dependable supplier is crucial. NINGBO INNO PHARMCHEM CO.,LTD. stands out as a premier manufacturer in China, dedicated to producing Fmoc-D-Cys(Trt)-OPfp with exceptional purity (typically >98%) and consistency. Our commitment to quality control ensures that each batch meets rigorous specifications, facilitating predictable and successful peptide synthesis outcomes. We also offer competitive price structures, particularly for bulk orders, making high-quality peptide synthesis reagents accessible for a wide range of projects.

We encourage all researchers and development professionals in need of Fmoc-D-Cys(Trt)-OPfp to explore the offerings from NINGBO INNO PHARMCHEM CO.,LTD. Our expertise in chemical synthesis and supply chain management ensures you receive a product that meets your exact requirements, supporting your efforts in advancing peptide chemistry and its applications.