The landscape of chemical synthesis is continually evolving, with a persistent demand for high-quality intermediates that facilitate complex molecular construction. Fmoc-L-alaninol, a derivative of the amino acid L-alanine, is one such compound that has garnered significant attention due to its versatility and critical role in various synthetic applications. With its unique chemical structure and the protective Fmoc group, it serves as an essential building block for researchers and industrial chemists alike. Understanding its properties and sourcing channels is key for any organization involved in advanced chemical manufacturing.

Fmoc-L-alaninol, bearing the CAS number 161529-13-1, is characterized by its molecular formula C18H19NO3 and a molecular weight of approximately 297.35 g/mol. The defining feature is the 9-fluorenylmethoxycarbonyl (Fmoc) group, which is appended to the amino nitrogen. This protecting group is renowned in peptide synthesis for its orthogonal deprotection chemistry – it can be efficiently removed using mild bases like piperidine, without affecting other common protecting groups such as Boc (tert-butyloxycarbonyl) or sensitive functional groups elsewhere in the molecule. This selectivity is crucial for building complex peptide chains step-by-step, ensuring that only the intended amino group is deprotected for coupling at each stage.

The physical appearance of Fmoc-L-alaninol is typically a white to off-white powder, with reported purities of 98% or higher. This level of purity is essential for demanding applications like pharmaceutical synthesis, where even minor impurities can lead to significant issues in downstream processing and final product quality. For R&D scientists and procurement managers looking to buy Fmoc-L-alaninol, sourcing from reliable manufacturers that provide detailed Certificates of Analysis (CoA) is a critical step. These documents confirm the product's specifications, including purity, and are vital for quality assurance and regulatory compliance. Working with manufacturers, particularly those with established operations in regions like China, can often provide competitive pricing and ensure a stable, dependable supply.

The applications of Fmoc-L-alaninol are predominantly found in peptide synthesis, where it acts as a chiral building block. Its incorporation into peptide sequences is fundamental for creating peptides used in various research areas, including drug discovery, diagnostics, and the development of novel biomaterials. Beyond traditional peptide synthesis, its structure may also lend itself to other areas of organic synthesis where a protected amino alcohol moiety is required. The ability to procure this intermediate efficiently and at a reasonable price point directly impacts the feasibility and cost-effectiveness of many advanced chemical projects.

In summary, Fmoc-L-alaninol is a versatile and essential intermediate in modern chemical synthesis. Its well-defined chemical properties and the utility of the Fmoc protecting group make it a cornerstone for peptide synthesis and pharmaceutical research. By understanding its characteristics and the advantages of sourcing from reputable manufacturers, professionals can ensure the quality and continuity of their critical chemical supply chains.