For researchers engaged in peptide synthesis, selecting the right building blocks is crucial for success. Fmoc-L-alaninol, identified by CAS 161529-13-1, is a highly valued amino alcohol derivative that plays a significant role in constructing complex peptide sequences. This guide is designed to provide R&D scientists with essential information on its utility, handling, and procurement, emphasizing the importance of quality and reliable supply.

Fmoc-L-alaninol is an amino acid derivative where the amino group of L-alaninol is protected by the fluorenylmethoxycarbonyl (Fmoc) group. This protection strategy is central to modern solid-phase peptide synthesis (SPPS) and solution-phase techniques. The Fmoc group offers an advantage due to its base-lability, allowing for facile removal under mild conditions (typically using piperidine). This selective deprotection ensures that the amino acid can be efficiently coupled to the growing peptide chain without affecting other functional groups or the peptide backbone. The chemical formula for Fmoc-L-alaninol is C18H19NO3, with a molecular weight of approximately 297.35 g/mol. Its common physical form is a white or off-white powder, signifying high purity essential for synthesis.

The primary application of Fmoc-L-alaninol lies in the field of peptide synthesis, where it is used to introduce specific amino acid residues into a peptide chain. This is fundamental for creating peptides with desired biological activities, which are increasingly explored in drug discovery and development. Researchers also utilize it for synthesizing modified peptides, peptidomimetics, and other complex organic molecules. The consistent purity of Fmoc-L-alaninol, typically 98% or higher, is vital for achieving reproducible results and high yields in these intricate syntheses. Therefore, when looking to buy this intermediate, it is imperative to source from reputable manufacturers and suppliers who can guarantee consistent quality and provide detailed technical documentation, such as a Certificate of Analysis.

For R&D scientists, understanding the practical aspects of using Fmoc-L-alaninol is also important. While the article doesn't detail specific handling protocols, general good laboratory practices for fine chemicals should be followed, including storage in a cool, dry place. Ensuring a stable supply chain is paramount for ongoing research projects. Many organizations find it beneficial to establish relationships with manufacturers, particularly those known for producing high-quality pharmaceutical intermediates. The availability of competitive pricing and reliable delivery from suppliers in China can be a significant factor in project planning and budget management for research laboratories.

In conclusion, Fmoc-L-alaninol is an indispensable tool for R&D scientists engaged in peptide synthesis. Its chemical properties, combined with the strategic advantage of the Fmoc protecting group, make it a cornerstone for creating advanced peptides for various applications, from therapeutic development to fundamental biological research. Prioritizing quality and reliable sourcing from trusted manufacturers is key to maximizing its potential in the lab.