In the realm of peptide-based pharmaceuticals and advanced biochemical research, the ability to precisely modify peptides is crucial for enhancing their efficacy, stability, and targeted delivery. For researchers and manufacturers seeking sophisticated peptide building blocks, Fmoc-Lys(ivDde)-OH is a reagent that unlocks significant potential. As a leading manufacturer and supplier of high-quality chemical intermediates, we offer this vital compound, understanding its pivotal role in modern peptide chemistry.

The Versatility of the ivDde Protecting Group

The hallmark of Fmoc-Lys(ivDde)-OH lies in its side-chain protection strategy. The ivDde group, a derivative of the Dde group, provides an orthogonal protection mechanism for the ε-amino group of lysine. Unlike standard protecting groups that might be cleaved under the same conditions, the ivDde group is remarkably stable to the basic conditions typically used to remove the N-terminal Fmoc group during solid-phase peptide synthesis (SPPS). Crucially, it can be selectively removed using mild reagents like hydrazine or hydroxylamine. This selective cleavage allows chemists to expose the lysine side chain at a specific stage of synthesis, paving the way for targeted modifications.

Applications in Drug Delivery and Peptide Modification

The selective deprotection capability of Fmoc-Lys(ivDde)-OH makes it an invaluable tool for several critical applications:

  • PEGylation: Attaching polyethylene glycol (PEG) chains to peptides can significantly improve their pharmacokinetic profile, reduce immunogenicity, and enhance solubility. By using Fmoc-Lys(ivDde)-OH, researchers can ensure that PEGylation occurs site-specifically on the lysine side chain after its selective deprotection. This level of control is vital for optimizing therapeutic peptides. If you need to buy PEGylation-ready lysine, our Fmoc-Lys(ivDde)-OH is an excellent starting point.
  • Drug Conjugation: For peptide-drug conjugates (PDCs), where a potent small molecule drug is linked to a peptide carrier, precise conjugation is essential. The exposed lysine side chain, after ivDde removal, offers a reactive handle for attaching the drug payload, ensuring that the peptide retains its targeting specificity while delivering the therapeutic agent effectively. We are a reliable supplier for pharmaceutical intermediate needs.
  • Fluorescent and Affinity Labeling: In diagnostic applications and biochemical studies, peptides often need to be labeled with fluorescent tags or affinity probes. Fmoc-Lys(ivDde)-OH allows for the specific attachment of these labels to lysine residues, facilitating tracking, imaging, and purification processes. We offer competitive price points for bulk orders of these specialized reagents.
  • Branched Peptide Synthesis: The ability to selectively introduce functional groups onto the lysine side chain also facilitates the synthesis of branched peptides, which can offer advantages in stability and receptor binding compared to linear counterparts.

Quality and Reliability from a Trusted Manufacturer

As a leading chemical manufacturer, our commitment extends beyond simply providing a product. We ensure that our Fmoc-Lys(ivDde)-OH meets rigorous purity standards (typically ≥98%), which is critical for reproducible results in sensitive peptide synthesis and modification protocols. When you choose to purchase from us, you are partnering with a company that understands the scientific and commercial demands of the industry. Our goal is to support your research and development efforts by providing consistent, high-quality materials.

For researchers and pharmaceutical developers looking to push the boundaries of peptide science, Fmoc-Lys(ivDde)-OH is an indispensable component. Its unique protective group allows for a level of synthetic control that is vital for creating next-generation peptide therapeutics and diagnostic tools. Connect with us to explore how our high-purity Fmoc-Lys(ivDde)-OH can accelerate your projects and to inquire about wholesale price and supply for your manufacturing needs.