In the dynamic world of chemical synthesis, the demand for versatile and precisely controlled building blocks is ever-increasing. Amino acid derivatives, particularly those used in peptide synthesis and bioconjugation, are at the forefront of this innovation. Fmoc-Lys(ivDde)-OH stands out as a prime example of such a versatile reagent, offering unique advantages in both research and industrial applications. As a dedicated manufacturer and supplier of specialty chemicals, we provide high-purity Fmoc-Lys(ivDde)-OH to support a wide range of chemical endeavors.

The Foundation: Fmoc-Lys(ivDde)-OH Explained

At its core, Fmoc-Lys(ivDde)-OH is a protected form of the amino acid lysine. It features two key protecting groups: the Fmoc group on the α-amino terminus and the ivDde group on the ε-amino side chain. The Fmoc group is standard for Fmoc-based solid-phase peptide synthesis (SPPS) and is removed under basic conditions. What makes this compound particularly valuable is the ivDde protecting group. This group is designed to be orthogonal, meaning it can be selectively removed under conditions that do not affect the Fmoc group or other common protecting groups. Typically, the ivDde group is cleaved using hydrazine or hydroxylamine, providing a clean and controlled method for exposing the lysine side chain.

Beyond Basic Peptide Synthesis: Diverse Applications

While essential for standard peptide synthesis, the true power of Fmoc-Lys(ivDde)-OH lies in its ability to facilitate more complex chemical transformations:

  • Bioconjugation Strategies: The selectively cleavable ivDde group makes Fmoc-Lys(ivDde)-OH a cornerstone for bioconjugation. Once deprotected, the lysine side chain serves as a reactive handle for attaching various biomolecules or synthetic tags. This includes PEGylation to improve drug solubility and half-life, conjugation with fluorescent dyes for biological imaging, or linking peptides to surfaces for sensor development. Researchers seeking to buy reagents for advanced bioconjugation will find our product to be of exceptional quality.
  • Synthesis of Modified Peptides: Many peptides with therapeutic or diagnostic potential require specific modifications on their amino acid side chains. Fmoc-Lys(ivDde)-OH allows for the precise introduction of functionalities onto the lysine side chain, such as glycosylation mimics, cross-linking agents, or specific pharmacophores. Our company is a trusted supplier for these specialized intermediate needs.
  • Branched and Cyclic Peptide Architectures: The ability to selectively deprotect and functionalize the lysine side chain enables the creation of complex peptide architectures, including branched peptides and cyclic peptides. These structures can exhibit enhanced stability, improved binding affinities, or novel biological activities.
  • Solid-Phase Organic Synthesis: Beyond peptide chemistry, amino acid derivatives like Fmoc-Lys(ivDde)-OH can also be employed in other solid-phase organic synthesis strategies, where controlled functionalization of amine groups is required.

Quality and Availability from a Premier Supplier

As a leading chemical manufacturer, we are committed to delivering products of the highest purity and consistency. Our Fmoc-Lys(ivDde)-OH typically boasts a purity of ≥98%, ensuring reliable performance in sensitive chemical reactions. We understand the critical need for dependable raw materials in both research laboratories and industrial production settings. Therefore, we ensure a robust supply chain and competitive price points for our products. When you are ready to purchase this versatile building block, trust our expertise as a leading supplier in China to meet your requirements.

Fmoc-Lys(ivDde)-OH is more than just a protected amino acid; it is a versatile tool that empowers chemists to achieve greater precision and complexity in their synthetic endeavors. Its unique orthogonal protection strategy opens up a world of possibilities for modification and conjugation, making it an indispensable reagent in modern chemistry. Connect with us to secure a reliable supply and elevate your chemical synthesis projects.