NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing critical chemical intermediates that form the backbone of advanced pharmaceutical products. Among these, Gimeracil (CAS 103766-25-2) stands out for its indispensable role in the development and efficacy of modern cancer therapies.

Gimeracil is a pyridine derivative with a molecular formula of C5H4ClNO2 and a molecular weight of 145.54. It is chemically known as 5-chloro-4-hydroxy-2(1H)-pyridinone. Its primary function in pharmaceutical applications is as an enhancer for fluoropyrimidine-based chemotherapies, most notably 5-fluorouracil (5-FU). The compound achieves this by inhibiting the enzyme dihydropyrimidine dehydrogenase (DPYD), which is responsible for breaking down 5-FU. This inhibition prolongs the presence of 5-FU in the bloodstream, thereby increasing its antitumor activity and allowing for potentially lower, more manageable doses.

The significance of Gimeracil as a Gimeracil pharmaceutical intermediate cannot be overstated. It is a critical component in combination therapies such as S-1, where it works synergistically with tegafur and oteracil. This combination is approved in many regions for treating advanced gastric cancer, and its use is being explored for other malignancies, highlighting the broad potential of Gimeracil in cancer treatment.

Our commitment at NINGBO INNO PHARMCHEM CO.,LTD. is to supply Gimeracil that meets the highest standards of purity and quality, essential for pharmaceutical manufacturing. We understand that the precision of a Gimeracil synthesis directly impacts the safety and efficacy of the final drug product. Therefore, our production facilities are equipped with advanced technology and adhere to rigorous quality control measures.

The consistent quality of our Gimeracil ensures reliable performance in downstream synthesis, allowing pharmaceutical companies to confidently develop and produce life-saving medications. By focusing on the Gimeracil DPYD inhibitor mechanism, researchers can further optimize treatment regimens, potentially leading to improved patient outcomes and reduced side effects. The compound's role in potentially sensitizing cancer cells to radiotherapy also points to its future importance in multidisciplinary cancer care.

For any pharmaceutical company or research institution looking for a dependable source of Gimeracil, NINGBO INNO PHARMCHEM CO.,LTD. offers a robust supply chain and consistent product quality. We support the vital work of advancing cancer therapies through the provision of essential pharmaceutical intermediates. Explore the possibilities with Gimeracil and enhance your drug development efforts.