NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying critical chemical components that enable sophisticated pharmaceutical treatments. Gimeracil (CAS 103766-25-2) is a key ingredient in advanced combination therapies, most notably within the S-1 regimen, which has demonstrated significant efficacy in treating various cancers.

The S-1 formulation is an oral chemotherapy regimen that combines three active components: tegafur, gimeracil, and oteracil potassium. Tegafur serves as a prodrug that is converted into 5-fluorouracil (5-FU), a widely used antimetabolite chemotherapy drug. Gimeracil's primary role in this combination is to inhibit the enzyme dihydropyrimidine dehydrogenase (DPYD). As the rate-limiting enzyme in the catabolism of 5-FU, DPYD's inhibition by Gimeracil leads to a substantial increase in the plasma levels of 5-FU. This prolonged exposure enhances the drug's cytotoxic effect on cancer cells.

The strategic use of Gimeracil enhancing 5-FU efficacy is a cornerstone of the S-1 regimen's success. By preventing the rapid breakdown of 5-FU, Gimeracil allows for a more sustained and potent antineoplastic effect. Oteracil potassium, the third component, further contributes by reducing gastrointestinal toxicity, a common side effect of 5-FU. This multi-pronged approach, facilitated by Gimeracil’s biochemical action, optimizes treatment and patient tolerance.

The clinical impact of the S-1 regimen, featuring Gimeracil, is significant. It is approved for treating advanced gastric cancer, and its effectiveness is being explored in other malignancies, including colorectal, lung, breast, and pancreatic cancers. The Gimeracil in cancer treatment applications highlights its broad therapeutic relevance.

As a reputable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity Gimeracil that meets stringent pharmaceutical standards. Our manufacturing processes ensure the consistent quality of this vital Gimeracil pharmaceutical intermediate. We are committed to supporting the pharmaceutical industry's efforts to develop and deliver effective combination therapies that improve patient lives. By understanding the critical role of compounds like Gimeracil, we aim to be a trusted partner in advancing global health.

For companies seeking to incorporate Gimeracil into their product development, our expertise and reliable supply chain ensure a consistent source of this vital compound. Partner with us to explore the potential of advanced chemotherapies.