The global market for specialized chemical intermediates is driven by demand from the pharmaceutical, agrochemical, and fine chemical sectors. 6-Hydroxy-5-nitronicotinic acid (CAS: 6635-31-0) is one such compound, critical for various synthetic processes. Understanding the landscape of manufacturers, pricing structures, and optimal procurement strategies is essential for businesses aiming to secure a stable and cost-effective supply of this vital intermediate.

Key Manufacturers and Suppliers

The production of 6-Hydroxy-5-nitronicotinic acid is concentrated among specialized chemical manufacturers, with a significant portion of the global supply originating from China. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are prominent players, offering this intermediate with high purity (typically ≥98.0%) and in various quantities, from research-scale grams to industrial-scale kilograms and metric tons. These manufacturers often specialize in pyridine derivatives and other complex organic intermediates, leveraging their expertise in synthesis and purification technologies. Other global suppliers also exist, but Chinese manufacturers frequently offer competitive pricing due to economies of scale and robust chemical production infrastructure.

Understanding Pricing and Packaging

The price of 6-Hydroxy-5-nitronicotinic acid can fluctuate based on several factors, including order volume, purity requirements, and prevailing market conditions for raw materials. For smaller R&D quantities, prices can range from tens to hundreds of dollars per gram. However, for bulk procurement, the price per kilogram decreases significantly. Manufacturers typically offer tiered pricing structures to incentivize larger purchases. Standard packaging for industrial supply often involves 25 kg drums, ensuring safe transport and storage. When requesting a quote, it is advisable to specify the exact quantity, desired purity, and delivery location to receive accurate pricing and lead time information.

Procurement Strategies for Reliability and Cost-Effectiveness

For procurement managers, securing a reliable supply chain for 6-Hydroxy-5-nitronicotinic acid involves a strategic approach:

  1. Supplier Vetting: Identify and vet manufacturers based on their production capacity, quality control systems (e.g., ISO certifications), and track record. Requesting Certificates of Analysis (CoAs) for each batch is crucial to verify purity and identity.
  2. Bulk Purchasing: For ongoing production needs, negotiating long-term supply agreements and placing larger orders can lead to significant cost savings and ensure consistent availability.
  3. Lead Time Management: Understand the production and shipping lead times from your chosen supplier to avoid supply chain disruptions. Proactive ordering is recommended.
  4. Technical Support: Partner with suppliers who offer strong technical support, providing insights into product specifications, handling, and application advice.
  5. Geographic Diversification: While China is a major supplier, considering secondary suppliers in different regions can mitigate risks associated with geopolitical or logistical disruptions.

Quality Control and Specifications

Ensuring the quality of purchased 6-Hydroxy-5-nitronicotinic acid is paramount. Key specifications to verify include its appearance (yellow solid), assay (≥98.0%), and adherence to specified melting point ranges (269-271°C). Manufacturers should be able to provide comprehensive analytical data, including NMR, IR, and MS spectra, to confirm the compound's identity and purity. Understanding the synthesis route employed by the manufacturer can also offer insights into potential impurities and their impact on downstream processes.

Conclusion

6-Hydroxy-5-nitronicotinic acid is a critical intermediate for various industries, with a robust global supply chain primarily driven by manufacturers in China. By implementing strategic procurement practices, focusing on supplier quality, and understanding market dynamics, businesses can effectively secure the necessary quantities of this vital chemical, thereby supporting their research, development, and manufacturing objectives. Engaging with reliable partners like NINGBO INNO PHARMCHEM CO.,LTD. is key to achieving these goals.