The pharmaceutical industry constantly seeks novel molecular scaffolds and versatile building blocks to accelerate drug discovery and development. Among these, piperazine derivatives have emerged as a particularly important class, forming the core structure of numerous successful therapeutic agents. One such derivative, 1-(Cyclopropylcarbonyl)piperazine (CAS 59878-57-8), exemplifies the utility and growing demand for these specialized organic intermediates.

Why Piperazine Derivatives are Key in Pharmaceuticals

The piperazine ring, a six-membered heterocycle containing two nitrogen atoms, offers several advantages in medicinal chemistry. Its basic nitrogen atoms can form salt bridges with biological targets, enhancing binding affinity. The ring’s conformation is relatively rigid, allowing for precise orientation of attached functional groups. Furthermore, the piperazine moiety can improve pharmacokinetic properties such as solubility and bioavailability. These attributes make piperazine derivatives a favored structural motif in drugs targeting the central nervous system (CNS), cardiovascular diseases, and oncology.

1-(Cyclopropylcarbonyl)piperazine: A Valuable Building Block

1-(Cyclopropylcarbonyl)piperazine, characterized by its cyclopropylcarbonyl substitution on one of the nitrogen atoms, brings unique structural and electronic properties to the piperazine scaffold. Its molecular formula is C8H14N2O, and it is typically supplied as a liquid with a purity of 97% or higher. Its most prominent application is as a critical intermediate in the synthesis of Olaparib, a targeted therapy for certain types of cancer. The compound's structure facilitates the precise introduction of the cyclopropylcarbonyl group, which is integral to the activity of such APIs. For research scientists and procurement managers, sourcing high-quality 1-(Cyclopropylcarbonyl)piperazine is essential for consistent manufacturing outcomes.

Sourcing and Supply Chain Considerations

The demand for reliable suppliers of pharmaceutical intermediates like 1-(Cyclopropylcarbonyl)piperazine is significant. When you aim to buy 1-(cyclopropylcarbonyl)piperazine, partnering with a reputable pharmaceutical intermediate manufacturer is crucial. A supplier in China or globally must demonstrate consistent product quality, competitive pricing, and a stable supply chain to support continuous production. As a leading organic synthesis raw material provider, NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering the high-purity CAS 59878-57-8 required for your synthesis needs. We encourage you to request a quote to explore bulk purchasing options and sample availability.

The strategic importance of piperazine derivatives in modern drug development, exemplified by compounds like 1-(Cyclopropylcarbonyl)piperazine, underscores the need for dependable sourcing of these specialized chemical building blocks.