For chemists engaged in advanced organic synthesis, the selection of appropriate building blocks is fundamental to achieving desired molecular structures and functionalities. 1-(Cyclopropylcarbonyl)piperazine (CAS 59878-57-8) stands out as a versatile and crucial organic intermediate, particularly valued in pharmaceutical research and development. Its unique structural features, combining a piperazine ring with a cyclopropylcarbonyl group, impart specific reactivity that chemists can leverage.

Chemical Profile and Reactivity of 1-(Cyclopropylcarbonyl)piperazine

The compound, with the molecular formula C8H14N2O and molecular weight of 154.21, presents as a liquid with a typical appearance ranging from colorless to pale brown. Its physical properties, such as a boiling point of 120 °C at 0.15 mmHg and a density of 1.087 g/mL at 25 °C, provide chemists with essential data for reaction planning and process optimization. The presence of the secondary amine in the piperazine ring allows for facile N-alkylation or acylation reactions, while the carbonyl group can participate in various nucleophilic addition or condensation reactions. This dual functionality makes it an attractive component for constructing complex heterocyclic systems.

Applications in Pharmaceutical and Fine Chemical Synthesis

The primary application driving the demand for 1-(Cyclopropylcarbonyl)piperazine is its role as a key pharmaceutical intermediate. It is instrumental in the synthesis of various Active Pharmaceutical Ingredients (APIs), most notably in the production of Olaparib, a PARP inhibitor used in cancer therapy. Researchers looking to buy 1-(cyclopropylcarbonyl)piperazine for drug discovery or process development can rely on its established utility. As a reliable pharmaceutical intermediate manufacturer, we ensure that this building block is available to support your R&D pipelines and manufacturing needs. When you need to buy CAS 59878-57-8 for your synthesis projects, consider the quality and consistency offered by established suppliers.

Sourcing Considerations for Chemists

For synthetic chemists, ensuring the availability and quality of reagents like 1-(Cyclopropylcarbonyl)piperazine is critical. Partnering with a trusted organic synthesis raw material supplier ensures that you receive products that meet stringent purity requirements, facilitating successful reactions and reducing the need for extensive purification. Companies seeking to buy this essential compound can benefit from the expertise and reliable supply offered by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. We provide clear specifications and are ready to assist with inquiries regarding product availability and pricing.

By understanding the chemical properties and synthetic potential of 1-(Cyclopropylcarbonyl)piperazine, chemists can effectively integrate it into their synthetic strategies, driving innovation in pharmaceutical and fine chemical development.