In the intricate world of organic synthesis, the availability of high-quality chemical building blocks is fundamental to innovation and product development. 3,4-Dihydroxy-5-Nitrobenzaldehyde (CAS 116313-85-0) stands out as a particularly valuable compound, primarily due to its specific functional groups and its critical role as a pharmaceutical intermediate. This article delves into its properties and applications, highlighting why it is a sought-after material for researchers and manufacturers alike.

Chemical Profile of 3,4-Dihydroxy-5-Nitrobenzaldehyde

This organic compound is characterized by a benzaldehyde structure adorned with two hydroxyl groups and a nitro group. Typically presenting as a white to yellow crystalline powder, its chemical formula is C7H5NO5, with a molecular weight of approximately 183.12 g/mol. The presence of electron-donating hydroxyl groups and electron-withdrawing nitro groups imparts unique reactivity to the molecule. This chemical versatility makes it an ideal candidate for various synthetic pathways, enabling chemists to construct more complex molecules.

Applications in Advanced Organic Synthesis

The utility of 3,4-Dihydroxy-5-Nitrobenzaldehyde extends beyond its pharmaceutical intermediate role. Its structure allows for a range of chemical transformations:

  • Derivatization: The aldehyde group can undergo condensation reactions, oxidation, or reduction. The phenolic hydroxyl groups are susceptible to etherification or esterification. The nitro group can be reduced to an amine, opening pathways for further functionalization.
  • Building Block for Heterocycles: Its functional groups can participate in cyclization reactions to form various heterocyclic compounds, which are common motifs in pharmaceuticals and agrochemicals.
  • Research and Development: For scientists exploring new synthetic methodologies or designing novel molecular architectures, 3,4-Dihydroxy-5-Nitrobenzaldehyde serves as a reliable starting material. Its well-defined properties allow for predictable reaction outcomes, facilitating systematic studies.

Pharmaceutical Significance: The Entacapone Connection

A primary driver for the demand for 3,4-Dihydroxy-5-Nitrobenzaldehyde is its indispensable role in the synthesis of Entacapone. Entacapone is a vital drug used in the management of Parkinson's disease, functioning as a COMT inhibitor to enhance the efficacy of levodopa therapy. The precise synthesis of Entacapone relies heavily on the purity and consistent quality of its precursors, including 3,4-Dihydroxy-5-Nitrobenzaldehyde. Sourcing this intermediate from a reputable manufacturer ensures that the subsequent synthesis steps proceed without unforeseen complications, leading to a high-quality active pharmaceutical ingredient (API).

Choosing the Right Supplier

When seeking to buy 3,4-Dihydroxy-5-Nitrobenzaldehyde for your synthesis needs, it is crucial to partner with suppliers who prioritize quality and provide robust technical support. Manufacturers often offer this compound with purity levels of 98% or higher. As a dedicated supplier, we ensure that our 3,4-Dihydroxy-5-Nitrobenzaldehyde meets stringent specifications, making it an ideal choice for advanced organic synthesis and pharmaceutical intermediate applications. We offer competitive pricing and reliable supply, backed by comprehensive quality documentation.

By understanding the chemical properties and diverse applications of 3,4-Dihydroxy-5-Nitrobenzaldehyde, researchers and manufacturers can effectively leverage this compound to drive progress in chemical synthesis and pharmaceutical development. We are committed to being your trusted source for this essential chemical intermediate.