For professionals in the pharmaceutical industry, particularly those involved in the production of Parkinson's disease medication, understanding the supply chain for key intermediates is vital. 3,4-Dihydroxy-5-Nitrobenzaldehyde (CAS 116313-85-0) is one such critical intermediate, indispensable for the synthesis of Entacapone. This article provides essential information for buyers looking to secure a reliable supply of this compound, focusing on quality, sourcing, and manufacturing considerations.

The Crucial Role of 3,4-Dihydroxy-5-Nitrobenzaldehyde

3,4-Dihydroxy-5-Nitrobenzaldehyde is a complex organic molecule that serves as a precursor in the multi-step synthesis of Entacapone. Entacapone is a COMT inhibitor used alongside levodopa in Parkinson's disease therapy to prolong the action of levodopa and improve motor control. The efficacy and safety of the final Entacapone drug product are directly linked to the purity and quality of the intermediates used in its production. Therefore, sourcing 3,4-Dihydroxy-5-Nitrobenzaldehyde with high assay values (typically ≥99%) is a non-negotiable requirement for API manufacturers.

Key Factors When Purchasing

When a procurement manager or R&D scientist decides to buy 3,4-Dihydroxy-5-Nitrobenzaldehyde, they must consider several critical factors:

  • Quality Assurance: The primary concern is the purity of the compound. Manufacturers should provide detailed Certificates of Analysis (CoA) confirming the assay, impurity profile, and physical characteristics like appearance (often a white to yellow powder).
  • Manufacturing Capability: It is essential to partner with a manufacturer that has proven capabilities in producing this intermediate consistently and at scale. Certifications like ISO further attest to their quality management systems.
  • Supply Chain Reliability: Ensuring a stable and uninterrupted supply is crucial for pharmaceutical production schedules. Buyers should assess the supplier's production capacity, lead times, and inventory management.
  • Competitive Pricing and Terms: Obtaining quotes from various suppliers is standard practice. Beyond the unit price, consider bulk discounts, packaging options (e.g., aluminum foil bags, drums), and payment terms (e.g., T/T, L/C). Negotiation is key to securing cost-effective procurement.
  • Regulatory Support: Suppliers should be able to provide essential regulatory documents such as Material Safety Data Sheets (MSDS) and potentially information on the synthesis route (ROS) and method of analysis (MOA) if required for regulatory filings.

How to Find Reliable Suppliers

Identifying trustworthy manufacturers and suppliers for 3,4-Dihydroxy-5-Nitrobenzaldehyde is often done through:

  • B2B Chemical Marketplaces: Platforms listing chemical suppliers globally are invaluable resources. Searching for '3,4-Dihydroxy-5-Nitrobenzaldehyde manufacturer' or 'CAS 116313-85-0 for sale' will yield many results.
  • Industry Connections: Networking at pharmaceutical and chemical trade shows or leveraging existing industry relationships can lead to trusted supplier recommendations.
  • Direct Outreach: Companies specializing in pharmaceutical intermediates often have dedicated sales and technical teams ready to respond to inquiries.

We, as a dedicated manufacturer and supplier of fine chemicals and pharmaceutical intermediates, understand the critical nature of compounds like 3,4-Dihydroxy-5-Nitrobenzaldehyde. We are committed to providing high-purity material, competitive pricing, and reliable global supply. Our focus is on building long-term partnerships by ensuring the quality and consistency that the pharmaceutical industry demands. When you choose us, you are partnering with a supplier dedicated to the success of your Entacapone manufacturing process.