In the pharmaceutical industry, the quality of starting materials and intermediates directly impacts the efficacy and safety of the final drug product. 3-Methylbiphenyl, also known by its CAS number 643-93-6 and alternative names like 3-phenyltoluene, is a key organic intermediate that plays a vital role in the synthesis of complex pharmaceutical compounds. This article highlights the importance of sourcing high-purity 3-Methylbiphenyl and provides insights for researchers and procurement specialists seeking reliable suppliers.

The Chemical Identity of 3-Methylbiphenyl

3-Methylbiphenyl (CAS 643-93-6) is an aromatic hydrocarbon with the molecular formula C₁₃H₁₂. It features a biphenyl structure where a methyl group is attached at the 3-position of one of the phenyl rings. This specific arrangement of atoms dictates its chemical reactivity and physical properties. Typically presented as an off-white to white powder or a clear, light yellow liquid, it has a melting point of approximately 4-5°C and a boiling point of around 272°C. These characteristics make it suitable for various synthetic transformations.

Applications in Pharmaceutical Synthesis

The primary utility of 3-Methylbiphenyl lies in its function as a crucial intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs). The biphenyl moiety is a prevalent structural element in many drug molecules, contributing to their biological activity and pharmacokinetic profiles. Specific applications include:

  • Drug Development: Researchers utilize 3-Methylbiphenyl as a starting material or intermediate in the synthesis of compounds with potential therapeutic benefits, such as anti-inflammatory agents, antibacterial compounds, and immunomodulators.
  • Custom Synthesis: For specialized drug discovery projects, custom synthesis services often employ intermediates like 3-Methylbiphenyl to build novel chemical entities with tailored properties.
  • Agrochemicals: Beyond human pharmaceuticals, this compound can also serve as an intermediate in the synthesis of certain agrochemicals.

Sourcing High-Purity 3-Methylbiphenyl

For pharmaceutical research and manufacturing, obtaining 3-Methylbiphenyl with high purity (typically 97% or higher) is essential. Impurities can lead to side reactions, reduced yields, and potential contamination of the final product, which is critical in regulated industries. When seeking to buy this compound, it is advisable to:

  • Identify Reputable Manufacturers: Look for established chemical manufacturers and suppliers, particularly those with a strong presence in China, known for their production capacity and competitive pricing.
  • Verify Purity and Specifications: Always request a Certificate of Analysis (CoA) to confirm the product's purity and other critical parameters. Techniques like GC-MS and NMR are standard for verifying identity and purity.
  • Compare Suppliers: Utilize online platforms and industry directories to compare prices and terms from various suppliers. Many offer free samples for initial evaluation.
  • Ensure Reliable Supply: For ongoing projects, securing a supplier with a stable supply chain and consistent product quality is vital.

Partnering for Success

As a leading supplier of fine chemicals and pharmaceutical intermediates, we are dedicated to providing researchers with access to high-quality 3-Methylbiphenyl. Our commitment to excellence ensures that you receive a product that meets rigorous industry standards, facilitating your critical research and development efforts. We offer competitive pricing for bulk purchases and provide comprehensive technical documentation. Contact us to learn more or to request a quote for your specific needs.