Hydrocinnamoyl Chloride: A Versatile Building Block in Organic Synthesis
The field of organic synthesis is constantly seeking versatile and reactive molecules to build complex chemical structures. Hydrocinnamoyl Chloride, identified by CAS number 645-45-4, is one such compound that plays a crucial role as a building block. While well-known as a pharmaceutical intermediate, its utility extends to broader applications in organic chemistry.
As an acyl chloride, Hydrocinnamoyl Chloride possesses a highly electrophilic carbonyl carbon, making it an excellent reagent for acylation reactions. This reactivity allows for the efficient formation of various functional groups, including esters, amides, and anhydrides, through reactions with alcohols, amines, and carboxylic acids, respectively. The hydrocinnamoyl moiety it introduces can impart specific physical or biological properties to the target molecules.
Beyond its significant role in pharmaceutical synthesis, particularly for antivirals and antitumor agents, Hydrocinnamoyl Chloride finds application in the creation of specialty chemicals. Its structure, derived from 3-phenylpropionic acid, can be incorporated into polymers, fragrances, or other fine chemical products where the phenylpropyl group is desired. The ability to easily modify this structure via its reactive chloride makes it a flexible tool for chemists designing new materials or compounds.
The typical specifications for Hydrocinnamoyl Chloride, such as a purity of over 98.0% (GC) and its liquid state (clear, colorless to light yellow), ensure its reliable performance in diverse synthetic endeavors. When considering its use, understanding its moisture sensitivity and proper storage conditions is important to maintain its reactivity and prevent degradation.
In conclusion, Hydrocinnamoyl Chloride (CAS 645-45-4) is a valuable and versatile building block for organic chemists. Its inherent reactivity and the unique structural features it can introduce make it an important compound for a wide range of synthetic applications, extending its importance beyond its well-established role in the pharmaceutical industry.
Perspectives & Insights
Logic Thinker AI
“While well-known as a pharmaceutical intermediate, its utility extends to broader applications in organic chemistry.”
Molecule Spark 2025
“As an acyl chloride, Hydrocinnamoyl Chloride possesses a highly electrophilic carbonyl carbon, making it an excellent reagent for acylation reactions.”
Alpha Pioneer 01
“This reactivity allows for the efficient formation of various functional groups, including esters, amides, and anhydrides, through reactions with alcohols, amines, and carboxylic acids, respectively.”