Hydrocinnamoyl Chloride, bearing the CAS number 645-45-4, is a chemical compound of significant interest, particularly within the realms of organic synthesis and pharmaceutical development. As a derivative of phenylpropionic acid, it belongs to the class of acyl chlorides, known for their high reactivity and utility as intermediates.

Chemically, Hydrocinnamoyl Chloride is characterized by its molecular formula C9H9ClO and a molecular weight of 168.62 g/mol. Its physical properties include a melting point in the range of -7 to -5 °C and a boiling point of approximately 107 °C at 11 mm Hg. It typically presents as a clear, colorless to light yellow liquid. Its reactivity stems from the acyl chloride functional group, making it susceptible to hydrolysis and readily participating in reactions with nucleophiles such as alcohols, amines, and thiols. These reactions are fundamental for creating esters, amides, and thioesters, respectively, which are common motifs in many biologically active molecules.

The primary application of Hydrocinnamoyl Chloride lies in its role as a pharmaceutical intermediate. It is instrumental in the synthesis of a broad spectrum of pharmaceutical compounds, notably including antiviral agents and antitumor drugs. Researchers utilize its reactive nature to construct complex molecular architectures required for these therapeutic applications. For example, it can be a key component in the multi-step synthesis pathways leading to new drug candidates designed to combat diseases.

In the broader context of organic synthesis, Hydrocinnamoyl Chloride serves as a valuable reagent for introducing the hydrocinnamoyl group into various molecules. This can be crucial for modifying the properties of existing compounds or for building novel chemical entities with specific functionalities. Its availability from reputable manufacturers ensures researchers have access to a reliable source for this important fine chemical.

Understanding the chemical properties and application spectrum of Hydrocinnamoyl Chloride (CAS 645-45-4) is essential for anyone working in synthetic organic chemistry or pharmaceutical research. Its role as a versatile intermediate solidifies its importance in advancing both scientific understanding and therapeutic innovation.