In the complex world of pharmaceutical development and advanced chemical synthesis, understanding the specific properties and reliable sourcing of key intermediates is crucial. Imatinib Mesylate, identified by CAS number 220127-57-1, is a prime example of such a compound, widely used in scientific research and drug manufacturing.

Chemical Profile and Mechanism of Action

Imatinib Mesylate is a synthetic compound known for its potent and selective inhibitory action against specific tyrosine kinases. Its molecular structure facilitates binding to the ATP-binding site of these enzymes, thereby blocking their activity. This targeted approach is fundamental to its therapeutic effects, particularly in conditions like chronic myelogenous leukemia (CML) where the Bcr-Abl fusion protein is overactive. Researchers often rely on the precise chemical specifications and purity of Imatinib Mesylate to achieve accurate experimental outcomes.

Key properties often sought when one wishes to buy Imatinib Mesylate include:

  • High Purity: Typically specified as >99%, ensuring reliability in assays and synthesis.
  • Physical Form: Often described as a white to off-white crystalline powder.
  • Solubility: Soluble in water, DMSO, and DMF, facilitating various experimental setups.

Therapeutic and Research Applications

The primary applications of Imatinib Mesylate revolve around its role as a treatment for certain cancers and as a research chemical. Its significance extends to:

  • Oncology: As a primary treatment for CML and gastrointestinal stromal tumors (GIST).
  • Research Tools: Used in laboratories to study cellular signaling pathways, kinase inhibition, and drug resistance mechanisms.
  • Pharmaceutical Synthesis: As a crucial intermediate in the production of finished pharmaceutical products.

For procurement managers, the ability to consistently purchase Imatinib Mesylate with guaranteed quality is essential for project continuity.

Sourcing Strategy: Partnering with Manufacturers

When procuring Imatinib Mesylate, it is highly recommended to engage with reputable chemical suppliers and manufacturers. These entities often provide:

  • Quality Assurance: Detailed Certificates of Analysis (CoA) and adherence to industry standards.
  • Competitive Pricing: Offering advantageous Imatinib Mesylate price structures, especially for bulk orders.
  • Technical Support: Access to experts for product-related inquiries and application guidance.
  • Reliable Supply: Ensuring timely delivery and consistent availability.

Companies like Ningbo Inno Pharmchem Co., Ltd., a dedicated manufacturer and supplier of pharmaceutical intermediates, are well-positioned to meet these demands. By choosing such a partner, researchers and manufacturers can secure the high-quality Imatinib Mesylate necessary for their critical work.