In the relentless pursuit of effective cancer treatments, specific chemical compounds play pivotal roles as research tools and building blocks for novel therapies. Imatinib Mesylate (CAS 220127-57-1) is one such compound, widely recognized for its therapeutic action and its importance as a pharmaceutical intermediate. For research scientists and procurement specialists, understanding its properties and how to source it efficiently is vital.

The Scientific Significance of Imatinib Mesylate

Imatinib Mesylate is renowned as a tyrosine kinase inhibitor. Its primary mechanism involves targeting the Bcr-Abl fusion protein, a key driver of chronic myelogenous leukemia (CML). By inhibiting this aberrant kinase activity, Imatinib Mesylate effectively halts the proliferation of cancer cells. Beyond CML, it also demonstrates inhibitory effects on other kinases like PDGFR and c-Kit, making it a crucial agent in research for gastrointestinal stromal tumors (GIST) and other conditions driven by these signaling pathways.

Applications in Research and Development

As a high-purity chemical, Imatinib Mesylate is indispensable in several areas:

  • Targeted Therapy Research: Scientists utilize it to study the efficacy of tyrosine kinase inhibitors in various cancer models and to explore new therapeutic applications.
  • Drug Discovery: It serves as a lead compound or a reference standard in the discovery of new anti-cancer agents.
  • Biochemical Assays: Its precise inhibitory activity makes it ideal for screening enzyme activities and validating drug targets.
  • API Synthesis: For pharmaceutical companies, Imatinib Mesylate is a critical intermediate in the manufacturing process of the final drug product.

When looking to buy Imatinib Mesylate, it's important to ensure you are obtaining a product that meets rigorous purity standards, typically above 99%. This is crucial for the validity of experimental results and the safety of potential drug formulations.

Sourcing Imatinib Mesylate: Partnering with a Specialist Supplier

Finding a reliable supplier for Imatinib Mesylate is a critical step for any research institution or pharmaceutical company. A good supplier will offer not only the necessary purity but also:

  • Consistent Quality: Ensuring each batch meets the specified purity and impurity profiles.
  • Technical Documentation: Providing Certificates of Analysis (CoA), Safety Data Sheets (SDS), and any necessary regulatory information.
  • Supply Chain Stability: Guaranteeing a steady availability of the product to meet ongoing research or production demands.
  • Competitive Pricing: Offering fair Imatinib Mesylate price points for research-scale and bulk quantities.

For those seeking a dependable source, exploring options with established chemical manufacturers and suppliers in regions like China can be highly beneficial. Companies like Ningbo Inno Pharmchem Co., Ltd. specialize in providing high-quality pharmaceutical intermediates, making them a valuable partner for your research and development endeavors.