The advancement of antibacterial treatments relies heavily on innovative formulations that maximize the potency and duration of action of antibiotics. Cilastatin Sodium, a critical pharmaceutical intermediate with CAS number 1538-09-6, plays a pivotal role in this domain, particularly in its synergy with the broad-spectrum antibiotic Imipenem. For professionals in the pharmaceutical industry—from R&D scientists to procurement managers—understanding the function and sourcing of Cilastatin Sodium is key to developing and manufacturing effective treatments for severe bacterial infections.

Imipenem is renowned for its effectiveness against a wide array of Gram-positive and Gram-negative bacteria, including many resistant strains. However, its therapeutic potential is significantly enhanced by its combination with Cilastatin Sodium. The latter acts as an inhibitor of dehydropeptidase I, an enzyme found in the kidneys that would otherwise rapidly metabolize and inactivate Imipenem. By blocking this enzymatic activity, Cilastatin Sodium prolongs Imipenem's presence in the body, allowing it to exert its bactericidal effects for a longer period and at more effective concentrations. This makes high-purity Cilastatin Sodium an indispensable component for many critical injectable antibiotic formulations.

Pharmaceutical buyers often seek materials that guarantee reliability and compliance. Cilastatin Sodium, when sourced from reputable manufacturers, is typically supplied as a white crystalline powder with a purity exceeding 99%. This high level of purity is essential for pharmaceutical applications to ensure the safety and efficacy of the final drug product. Furthermore, adherence to Good Manufacturing Practices (GMP) is a crucial criterion. GMP-certified Cilastatin Sodium assures buyers that the manufacturing process meets stringent international standards for quality control, traceability, and consistency, thereby mitigating risks in drug production.

When considering the purchase of Cilastatin Sodium, understanding the pricing structure from various suppliers, particularly those in China, is important for cost-effective procurement. Manufacturers often offer tiered wholesale pricing based on order volume. Establishing a long-term supply agreement with a dependable supplier can also secure consistent availability and predictable pricing. For companies looking to buy this pharmaceutical intermediate, seeking detailed quotes and engaging in direct communication with manufacturers is recommended.

In summary, Cilastatin Sodium (1538-09-6) is more than just a chemical compound; it is a key enabler of powerful antibacterial therapies. Its role in preserving the efficacy of Imipenem makes it a highly sought-after pharmaceutical intermediate. By prioritizing purity, GMP compliance, and strategic sourcing from trusted manufacturers, pharmaceutical companies can ensure the quality and availability of their critical antibiotic formulations. Prospective buyers are encouraged to connect with leading suppliers to explore their offerings and obtain necessary pricing information.