The pharmaceutical industry's relentless pursuit of novel therapeutics increasingly relies on the precise synthesis of complex peptides. In this specialized field, the quality and availability of specific building blocks are paramount. 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride (CAS: 17193-40-7), often referred to as H-Phe(4-NO2)-OMe.HCl, stands out as a crucial modified amino acid derivative for sophisticated peptide synthesis workflows. Its unique chemical structure offers distinct advantages that are vital for pharmaceutical research and development.

Why H-Phe(4-NO2)-OMe.HCl is Indispensable for Peptide Synthesis:

This particular amino acid derivative is highly valued in peptide synthesis due to its specific modifications:

  • Nitro Group as a Functional Handle: The nitro group on the phenylalanine ring serves as a versatile handle for further chemical modifications. It can be selectively reduced to an amino group, enabling the attachment of fluorescent labels, cytotoxic payloads (in Antibody-Drug Conjugates or ADCs), or other functional moieties. This capability is instrumental in creating advanced peptide-based therapeutics and diagnostics.
  • Chiral Purity: As a derivative of L-phenylalanine, maintaining its stereochemical integrity (chirality) is essential. Pharmaceutical applications demand enantiomerically pure compounds to ensure proper biological activity and avoid potential side effects associated with incorrect stereoisomers. Procuring from reputable manufacturers is key to obtaining this purity.
  • Improved Solubility and Reactivity: The methyl ester protection on the carboxyl group can influence the compound's solubility in common peptide synthesis solvents and control its reactivity during coupling steps, leading to more efficient peptide bond formation.

Sourcing for Pharmaceutical Grade Peptides:

For pharmaceutical companies and contract manufacturing organizations (CMOs), sourcing H-Phe(4-NO2)-OMe.HCl requires a stringent approach:

  1. High Purity and Consistent Quality: A purity of ≥98% by HPLC is typically required, along with low levels of impurities and well-defined stereochemistry. Certificates of Analysis (CoA) are mandatory.
  2. Supplier Audits and Reliability: Pharmaceutical manufacturers often conduct rigorous audits of their key suppliers. A reliable manufacturer with a strong quality management system and a stable supply chain is essential to avoid production disruptions. We understand these stringent requirements and are prepared to meet them.
  3. Regulatory Compliance: While this compound is often an intermediate, understanding its manufacturing process and potential regulatory implications is important for pharmaceutical development.
  4. Scalability: The ability to source the compound from gram-scale for research to kilogram-scale for clinical trials and commercial production is a critical factor. We are a manufacturer capable of supporting various scales.

Choosing the Right Manufacturer: A Strategic Decision

When looking to 'buy 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride' or 'order H-Phe(4-NO2)-OMe.HCl', consider manufacturers in China that specialize in amino acid derivatives. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-quality chemical intermediates essential for drug development. Our focus on manufacturing excellence ensures that your peptide synthesis projects benefit from reliable starting materials at competitive prices. We pride ourselves on being a preferred supplier for the pharmaceutical industry.

By securing a dependable source for 4-Nitro-L-phenylalanine Methyl Ester Hydrochloride, pharmaceutical companies can accelerate their peptide-based drug discovery and development pipelines, bringing innovative therapies to market more efficiently.