The intricate process of developing and manufacturing pharmaceutical drugs relies heavily on the availability and quality of chemical intermediates. For Indacaterol, a crucial medication used in the management of COPD, 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (CAS 100331-89-3) is a linchpin intermediate. This article is tailored for R&D scientists and procurement professionals seeking to understand this compound's significance and how to effectively source it from experienced suppliers.

The Chemical Significance of CAS 100331-89-3

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, identified by CAS 100331-89-3, is characterized by its distinct chemical structure which lends itself to being a precise precursor in the synthesis of Indacaterol. Its molecular formula is C18H14BrNO3, and it typically presents as an off-white powder with an assay purity often exceeding 98.0%. For R&D purposes, this high purity is critical as it minimizes confounding variables in experimental reactions, allowing for more accurate assessment of synthesis pathways and optimization. The bromoacetyl functional group is particularly important for subsequent chemical modifications required to build the Indacaterol molecule.

Applications in Pharmaceutical Development

The primary application of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline is its role as a direct intermediate in the manufacturing of Indacaterol. Indacaterol is a long-acting beta2-agonist that provides bronchodilation, alleviating respiratory distress in patients with COPD. Pharmaceutical companies developing or manufacturing Indacaterol Maleate (the common salt form) rely on a consistent supply of this intermediate. Beyond its direct use in Indacaterol synthesis, researchers may explore its reactivity and structural features for other novel chemical entities or in combinatorial chemistry libraries, although its primary market remains within the Indacaterol production chain.

Sourcing Strategies for Buyers

When looking to buy 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, R&D scientists and procurement managers should prioritize suppliers who can offer both quality and reliability. Experienced suppliers will readily provide detailed product specifications, including purity analysis (e.g., HPLC reports) and relevant safety documentation (MSDS). As a leading manufacturer and supplier, we understand these needs and ensure our product meets rigorous quality standards. We also emphasize the importance of stable supply chains, offering flexible packaging and shipping options to cater to diverse R&D and production scales. Engaging with a supplier that can provide samples for initial evaluation is also a best practice.

Market Insights and Supplier Support

The market for pharmaceutical intermediates can be competitive. Understanding that pricing for CAS 100331-89-3 can vary based on order volume and current market conditions is important. We encourage potential clients to request a quote to receive the most accurate pricing information. Beyond pricing, the value of a supplier lies in their support for their customers. This includes technical assistance, responsive communication, and a commitment to problem-solving. Our team is dedicated to providing comprehensive support to our clients, from initial inquiry through to delivery and beyond.

In conclusion, 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (CAS 100331-89-3) is a pivotal intermediate for Indacaterol manufacturing. By partnering with knowledgeable and quality-focused suppliers, R&D scientists and procurement teams can ensure the smooth progression of their drug development and production efforts.