In the realm of chemical synthesis, understanding the fundamental properties and applications of key intermediates is critical for innovation and efficient production. For the pharmaceutical industry, particularly in the synthesis of Indacaterol, 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (CAS 100331-89-3) plays a pivotal role. This article provides a detailed overview of its chemical characteristics and its essential applications, aimed at chemists, formulators, and procurement specialists.

Chemical Profile and Physical Characteristics

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, with the CAS number 100331-89-3, is a complex organic molecule with the molecular formula C18H14BrNO3 and a molecular weight of approximately 372.21 g/mol. Its typical physical appearance is an off-white to pale yellow powder, a characteristic that aids in its identification and handling during manufacturing processes. While specific solubility data might vary, it is generally handled in organic solvents common to pharmaceutical synthesis. Its structural features, including the quinoline ring system, the benzyloxy group, and the reactive bromoacetyl moiety, are key to its utility in complex synthetic pathways.

Reactivity and Synthesis Role

The bromoacetyl group (-COCH2Br) is highly reactive and serves as an excellent electrophile, making it ideal for nucleophilic substitution reactions. This reactivity is precisely what makes 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline an invaluable intermediate in the multi-step synthesis of Indacaterol. The molecule is designed to undergo specific transformations at controlled conditions, leading to the construction of the larger, pharmacologically active Indacaterol molecule. Researchers and process chemists leverage this inherent reactivity to achieve high yields and purity in their synthetic routes.

Key Applications in Pharmaceutical Manufacturing

The primary and most significant application of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline is its use as a critical intermediate in the manufacturing of Indacaterol. Indacaterol is a potent long-acting beta2-adrenergic agonist approved for the treatment of chronic obstructive pulmonary disease (COPD), offering patients long-lasting bronchodilation. The synthesis process involves several steps, and this intermediate is crucial for introducing key structural components of the final drug. Pharmaceutical companies worldwide rely on a consistent and high-quality supply of this intermediate to meet the global demand for Indacaterol Maleate.

Sourcing from a Reliable Manufacturer

For companies seeking to buy 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline, sourcing from a reputable manufacturer is paramount. As a leading supplier of this intermediate, we ensure rigorous quality control, typically achieving an assay purity of ≥98.0%. Our commitment extends to providing comprehensive product information, including safety data sheets and certificates of analysis, to support your R&D and manufacturing needs. We understand the importance of reliable supply chains and competitive pricing for pharmaceutical intermediates.

In conclusion, 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (CAS 100331-89-3) is more than just a chemical compound; it's a vital link in producing a drug that improves the lives of millions. Its specific chemical properties make it indispensable for Indacaterol synthesis, and reliable sourcing from experienced manufacturers ensures the continuity and quality of pharmaceutical production.