For scientists pushing the boundaries of medical and biological research, access to highly pure and well-characterized chemical compounds is fundamental. Podophyllotoxin (CAS 518-28-5) is one such compound that plays a significant role in various research disciplines, particularly in oncology, molecular biology, and pharmacology. Understanding its properties and how to source it effectively can accelerate research breakthroughs.

Podophyllotoxin: A Compound of Significant Biological Interest

Podophyllotoxin, a lignan extracted from plants, possesses potent biological activities that make it a valuable tool for scientific investigation. Its primary mechanism of action involves targeting the cellular cytoskeleton, specifically inhibiting tubulin polymerization. This disruption of microtubule dynamics leads to cell cycle arrest, making it a key subject of study in cancer research, where it serves as a precursor for several antimitotic chemotherapy drugs.

Beyond its antimitotic effects, Podophyllotoxin is investigated for its ability to induce apoptosis and its potential antiviral properties. Researchers leverage its unique chemical structure and bioactivity to explore new therapeutic strategies and understand fundamental cellular processes.

Key Considerations for Research-Grade Podophyllotoxin

When sourcing Podophyllotoxin for research purposes, several factors are paramount:

  • Purity: For scientific experiments, especially those involving cell-based assays or drug development, high purity is essential. Typically, research-grade Podophyllotoxin (CAS 518-28-5) should be of 98% to 99% purity, often verified by HPLC.
  • Source and Characterization: Understanding the origin of the compound and having access to its Certificate of Analysis (COA) is crucial. The COA should detail physical properties (like appearance: off-white crystalline powder), molecular formula (C22H22O8), molecular weight (414.41 g/mol), and purity assessment.
  • Solubility and Storage: Knowledge of its solubility in various solvents (e.g., ethanol, methanol, chloroform) and appropriate storage conditions (typically cool and dry, at 4°C) ensures experimental reproducibility.
  • Safety Information: Access to a Material Safety Data Sheet (MSDS) is necessary for safe handling and disposal, outlining potential hazards and protective measures.

Where to Source High-Quality Podophyllotoxin

For researchers worldwide, identifying reliable suppliers for high-purity compounds like Podophyllotoxin is critical. Many global research chemical providers source from established manufacturers, particularly in regions with strong chemical production capabilities such as China. When you choose to buy podophyllotoxin, look for suppliers who:

  • Specialize in research chemicals and pharmaceutical intermediates.
  • Offer detailed product specifications and readily available COAs and MSDSs.
  • Provide various quantities, from milligrams for initial screening to grams for more extensive studies.
  • Have a good reputation for quality and customer service.

When searching for a podophyllotoxin manufacturer or supplier, it's beneficial to look for those offering competitive pricing and efficient shipping. Companies that act as a cas 518-28-5 chemical exporter can ensure that research materials reach laboratories globally in a timely manner.

Conclusion

Podophyllotoxin (CAS 518-28-5) remains a cornerstone compound in scientific research, particularly in the development of antimitotic and antiviral agents. For researchers aiming to procure this vital chemical, focusing on purity, comprehensive documentation, and reliable suppliers is key. By leveraging the capabilities of global chemical suppliers, including those in China known for their manufacturing expertise, researchers can secure the high-quality Podophyllotoxin needed to drive their investigations forward.