For researchers and procurement managers in the pharmaceutical industry, securing high-quality raw materials is paramount. Podophyllotoxin (CAS 518-28-5) stands out as a crucial natural product derivative, indispensable as a pharmaceutical intermediate for developing potent anticancer and antiviral agents. Understanding where and how to source this compound is key to successful drug development and research.

What is Podophyllotoxin?

Podophyllotoxin is a lignan extracted from the roots and rhizomes of plants belonging to the *Podophyllum* genus. Its significance lies in its potent antimitotic and cytotoxic properties, primarily achieved by inhibiting microtubule assembly and interfering with DNA topoisomerase I. This mechanism makes it a foundational compound for drugs like etoposide and teniposide, widely used in cancer chemotherapy.

The Importance of Purity and Specifications

When considering Podophyllotoxin, purity is a critical factor. For pharmaceutical applications, especially as a direct intermediate, a high purity level, such as 99%, is often required. This ensures predictable efficacy, minimizes unwanted side reactions, and meets stringent regulatory standards. Always check the Certificate of Analysis (COA) for details on purity (e.g., by HPLC) and other specifications like molecular weight (414.41 g/mol) and appearance (off-white fine crystalline powder).

Key Applications in Pharmaceutical R&D

The primary application of Podophyllotoxin is as a precursor in the synthesis of various cytotoxic drugs. Its derivatives have shown remarkable efficacy against a range of cancers, including testicular, lung, breast, and ovarian cancers. Beyond oncology, its antiviral properties are also a subject of ongoing research. For those looking to buy podophyllotoxin 518-28-5, its role as a building block for these life-saving medications underscores its importance.

Navigating the Chinese Market: Manufacturers and Suppliers

China has emerged as a significant global hub for chemical manufacturing, including specialized pharmaceutical intermediates. When searching for a podophyllotoxin manufacturer in China or a reliable podophyllotoxin supplier, it's essential to look for companies with robust quality control systems, good manufacturing practices (GMP) compliance where applicable, and a proven track record. Look for suppliers who can provide detailed product documentation, including MSDS and COAs, and offer flexible shipping and payment terms.

Procurement Considerations: Price and Availability

The podophyllotoxin price for pharmaceutical intermediate use can vary based on purity, order volume, and the supplier. When requesting a price quote, be prepared to specify your required quantity and purity level. Understanding the typical lead times and minimum order quantities (e.g., 10 grams or 25kg/drum) is also crucial for effective inventory management. As a cas 518-28-5 chemical exporter, reputable Chinese suppliers can facilitate international trade with various Incoterms (FOB, CFR, CIF) and payment types (L/C, T/T, PayPal).

Conclusion

Sourcing Podophyllotoxin (CAS 518-28-5) requires careful consideration of purity, application, and supplier reliability. By partnering with established manufacturers and suppliers in China, pharmaceutical companies and research institutions can secure a consistent supply of this vital intermediate. For those seeking to purchase podophyllotoxin, focusing on quality, price, and dependable logistics will pave the way for successful drug discovery and development projects.