The intricate world of pharmaceutical synthesis relies heavily on high-quality chemical intermediates to build complex drug molecules. Isopropyl 2-bromo-2-methylpropanoate (CAS: 51368-55-9) is one such compound, playing a pivotal role in the creation of essential medicines. For R&D scientists and procurement professionals, understanding this intermediate—its properties, applications, and how to source it from reputable manufacturers and suppliers—is key to successful drug development and production.

Understanding the Chemical Profile

Isopropyl 2-bromo-2-methylpropanoate, a derivative of isobutyric acid, is characterized by its unique structure which includes a bromine atom and an isopropyl ester group. Typically appearing as a colorless to pale yellow liquid, its purity is a significant factor for its utility, with levels of ≥99.0% being standard for demanding applications. Its chemical formula is C7H13BrO2, and it has a molecular weight of approximately 209.08 g/mol. With a boiling point of 168-170°C and a flash point of 56°C, it requires proper handling and storage protocols to ensure safety and maintain its integrity.

The Synthesis Pathway: Esterification for Purity

The production of Isopropyl 2-bromo-2-methylpropanoate typically involves the esterification of 2-bromoisobutyric acid with isopropanol. This reaction is a cornerstone of its manufacturing process, and experienced manufacturers employ optimized conditions to achieve high yields and exceptional purity. The resulting intermediate is crucial for reactions where the introduction of specific chemical functionalities is required, making it a sought-after component in multi-step syntheses. The reliability of its synthesis directly impacts the quality of the downstream pharmaceutical products.

Critical Role in Pharmaceutical Synthesis

The primary significance of Isopropyl 2-bromo-2-methylpropanoate lies in its application as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Most notably, it is a key building block in the manufacturing of Elafibranor. Elafibranor is a drug developed for treating metabolic and liver diseases, such as non-alcoholic steatohepatitis (NASH). The reactive bromine atom allows for precise chemical modifications, enabling chemists to construct the complex molecular framework of such therapeutic agents. Its consistent availability and high purity are therefore essential for the pharmaceutical industry to meet the growing demand for effective treatments.

Sourcing and Procurement: Ensuring Quality and Value

When looking to buy Isopropyl 2-bromo-2-methylpropanoate, partnering with reputable suppliers and manufacturers is paramount. Companies in China are major producers, offering competitive pricing and significant production capacities. When selecting a supplier, it’s crucial to assess their quality control measures, their ability to provide comprehensive technical documentation (like CoAs), and their reliability in terms of delivery schedules. Considering factors such as packaging (e.g., 250 kg drums), minimum order quantities, and customer service can help ensure a smooth procurement process.

In conclusion, Isopropyl 2-bromo-2-methylpropanoate is more than just a chemical; it's an enabler of modern medicine. Its well-defined synthesis, high purity, and critical role in pharmaceutical production underscore its importance. By understanding these aspects and carefully selecting suppliers, R&D professionals and procurement specialists can ensure they have access to this essential intermediate, driving forward the development of life-saving treatments.