For procurement managers and R&D scientists in the chemical and pharmaceutical industries, sourcing high-quality intermediates is paramount. Isopropyl 2-bromo-2-methylpropanoate (CAS: 51368-55-9) stands out as a critical component, particularly in pharmaceutical synthesis. Understanding its properties, typical applications, and how to find reliable manufacturers and competitive pricing is essential for successful procurement. This article aims to guide you through the process of acquiring this vital chemical.

Understanding Isopropyl 2-Bromo-2-Methylpropanoate

Isopropyl 2-bromo-2-methylpropanoate is an organic compound characterized by its molecular formula C7H13BrO2 and a molecular weight of 209.08100. It typically presents as a colorless to pale yellow liquid. Its significance stems from its role as a versatile intermediate in organic synthesis, most notably in the pharmaceutical sector. A key application includes its use in the synthesis of Elafibranor, a compound used in the treatment of liver-related conditions. The presence of a bromine atom on the alpha-carbon makes it highly reactive and a valuable building block for creating more complex molecular structures.

Key Specifications and Quality Assurance

When looking to buy Isopropyl 2-bromo-2-methylpropanoate, paying close attention to specifications is crucial. The material is generally expected to have a purity of ≥99.0%, often verified through Gas Chromatography (GC). Other important parameters include moisture content (typically ≤0.1%) and pH (ranging from 6.0-8.0). These specifications ensure that the intermediate will perform reliably in synthesis reactions, minimizing unwanted side reactions and impurities in the final product. Reputable suppliers will provide detailed Certificates of Analysis (CoA) with each batch, confirming adherence to these critical quality standards.

Synthesis and Manufacturing Processes

The production of Isopropyl 2-bromo-2-methylpropanoate typically involves the esterification of 2-bromoisobutyric acid with isopropanol. This is a well-established chemical reaction that, when performed under controlled conditions by experienced manufacturers, yields a high-quality product. For businesses seeking to secure a stable supply, identifying Chinese manufacturers known for their robust production capabilities and stringent quality control protocols is a strategic move. These suppliers often leverage economies of scale, which can translate into more competitive pricing.

Navigating Pricing and Procurement

The price of Isopropyl 2-bromo-2-methylpropanoate can fluctuate based on raw material costs, production volume, and supplier. When making a purchasing decision, it’s advisable to obtain quotes from multiple reputable suppliers in China. Consider not only the per-kilogram cost but also factors such as packaging options (e.g., 250 kg drums), minimum order quantities, and lead times. Engaging with a manufacturer directly can often lead to better pricing and a more transparent understanding of the supply chain. Companies looking to secure long-term supply agreements may also negotiate favorable terms.

Applications and Market Relevance

Beyond its significant role in Elafibranor synthesis, Isopropyl 2-bromo-2-methylpropanoate is a versatile intermediate with potential applications in other areas of fine chemical synthesis and agrochemicals. Its reactivity makes it an attractive starting material for various organic transformations. For companies involved in the development of new pharmaceuticals or specialty chemicals, having a reliable source of this compound is indispensable. By choosing a trusted supplier, you ensure the smooth progression of your research and development pipelines and the efficient scale-up of your production processes.

In conclusion, sourcing Isopropyl 2-bromo-2-methylpropanoate requires a diligent approach to supplier selection, with a focus on purity, consistency, and competitive pricing. By understanding the product’s specifications and the capabilities of leading manufacturers and suppliers in China, businesses can secure a vital chemical intermediate that supports critical synthesis pathways and drives innovation.