The intricate world of Active Pharmaceutical Ingredient (API) synthesis relies on a diverse palette of chemical building blocks, each playing a unique role in constructing complex drug molecules. Among these vital components, indazole amines have gained significant traction due to their versatile chemical properties and their presence in numerous pharmacologically active compounds. One such prominent derivative is (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine, identified by its CAS number 886230-76-8.

Indazole amines, by their very nature, offer a rich chemical scaffold for modification and functionalization. The indazole core provides a stable aromatic system, while the amine group at the 6-position offers a reactive site for forming amide bonds, sulfonamides, or undergoing other derivatization reactions. The specific structure of (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine, with its pyridinyl ethenyl substituent and tetrahydropyranyl group, imparts unique electronic and steric properties, making it particularly useful in targeted drug design.

This particular compound has garnered attention as a key intermediate in the synthesis of Axitinib, a tyrosine kinase inhibitor used in cancer therapy. Its precise molecular formula, C19H20N4O, and molecular weight of 320.39, are critical parameters for synthetic chemists to ensure accurate stoichiometry and reaction outcomes. The high purity often required for such intermediates, typically exceeding 99%, is a testament to the stringent quality demands of the pharmaceutical industry. Buyers looking to purchase this compound often seek out specialized manufacturers who can guarantee these specifications.

The availability of such advanced intermediates from reliable suppliers is crucial for pharmaceutical companies and contract manufacturing organizations (CMOs). Sourcing from manufacturers in China, who often possess the expertise and infrastructure for complex organic synthesis, can provide access to these vital building blocks. For R&D scientists and procurement managers, understanding the role of these indazole amines in API synthesis helps in making informed decisions about material sourcing. By identifying reliable suppliers who can provide consistent quality and competitive pricing, the path from chemical synthesis to life-saving medication becomes more streamlined and efficient.

In summary, indazole amines like (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine are more than just chemical reagents; they are foundational components in the creation of modern medicines. Their strategic importance underscores the need for a robust global supply chain and close collaboration between chemical manufacturers and pharmaceutical developers.